LOCUS SIU01602.1 243 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 SAM-
dependent methyltransferases protein.
ACCESSION LT708304-3016
PROTEIN_ID SIU01602.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/locus_tag="BQ2027_MB2980"
/note="Mb2980, -, len: 243 aa. Equivalent to Rv2956, len:
243 aa, from Mycobacterium tuberculosis strain H37Rv,
(99.6% identity in 243 aa overlap). Conserved hypothetical
protein, highly similar to O86299|GSC GSC PROTEIN from
Mycobacterium avium subsp. silvaticum Mycobacterium avium
(240 aa), FASTA scores: opt: 1070, E(): 3.5e-63, (67.5%
identity in 240 aa overlap); and O86294|GSC GSC PROTEIN
from Mycobacterium paratuberculosis (240 aa), FASTA
scores: opt: 1070, E(): 3.5e-63, (67.5% identity in 240 aa
overlap). Also some similarity with other proteins from
other organisms e.g. Q9L727 NODULATION PROTEIN NOEI from
Rhizobium fredii (Sinorhizobium fredii) (241 aa), FASTA
scores: opt: 205, E(): 3.5e-06, (27.25% identity in 198 aa
overlap); Q9AGG1|LPEA LPEA PROTEIN from Rhizobium etli
(286 aa), FASTA scores: opt: 201, E(): 7.2e-06, (28.85%
identity in 208 aa overlap); P74191|SLL1173 HYPOTHETICAL
28.0 KDA PROTEIN Synechocystis sp. (strain PCC 6803) (244
aa), FASTA scores: opt: 274, E(): 1e-10, (30.65% identity
in 225 aa overlap); etc. Also highly similar to others
from Mycobacterium tuberculosis e.g.
P71792|RV1513|MTCY277.35 HYPOTHETICAL 26.7 KDA PROTEIN
(243 aa), FASTA scores: opt: 1105, E(): 1.7e-65, (70.05%
identity in 237 aa overlap); etc. Protein product from
Mb2980 detected using shotgun mass spectrometry and SWATH
mass spectrometry. Mb2980 found to be expressed during
exponential growth in Sauton's minimal media by
RNA-sequencing."
/db_xref="InterPro:IPR006342"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:A0A1R3Y2N6"
BEGIN
1 MKSLKLARFI ARSAAFEVSR RYSERDLKHQ FVKQLKSRRV DVVFDVGANS GQYAAGLRRA
61 AYKGRIVSFE PLSGPFTILE SKASTDPLWD CRQHALGDSD GTVTINIAGN AGQSSSVLPM
121 LKSHQNAFPP ANYVGTQEAS IHRLDSVAPE FLGMNGVAFL KVDVQGFEKQ VLAGGKSTID
181 DHCVGMQLEL SFLPLYEGGM LIPEALDLVY SLGFTLTGLL PCFIDANNGR MLQADGTFFR
241 EDD
//