LOCUS SIU01599.1 418 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 enoyl
reductase protein.
ACCESSION LT708304-3013
PROTEIN_ID SIU01599.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/locus_tag="BQ2027_MB2977"
/note="Mb2977, -, len: 418 aa. Equivalent to Rv2953, len:
418 aa, from Mycobacterium tuberculosis strain H37Rv,
(100.0% identity in 418 aa overlap). Conserved
hypothetical protein, equivalent to Q9CD87|ML0129
HYPOTHETICAL PROTEIN from Mycobacterium leprae (418 aa),
FASTA scores: opt: 2357, E(): 2.7e-143, (86.6% identity in
418 aa overlap). Also highly similar to Q9X7N5|SC5F2A.12c
CONSERVED HYPOTHETICAL PROTEIN from Streptomyces
coelicolor (396 aa), FASTA scores: opt: 491, E(): 7e-24,
(38.35% identity in 417 aa overlap); and similar to other
hypothetical proteins e.g. Q9VG81 CG5167 PROTEIN from
Drosophila melanogaster (Fruit fly) (431 aa), FASTA
scores: opt: 393, E(): 1.4e-17, (26.55% identity in 433 aa
overlap); Q9GZE9|F22F7.1 HYPOTHETICAL PROTEIN from
Caenorhabditis elegans (426 aa), FASTA scores: opt: 338,
E(): 4.6e-14, (27.05% identity in 425 aa overlap);
P73855|SLL1601 HYPOTHETICAL 44.8 KDA PROTEIN from
Synechocystis sp. (strain PCC 6803) (414 aa), FASTA
scores: opt: 565, E(): 1.3e-28, (35.7% identity in 409 aa
overlap); etc. Also highly similar to other proteins from
Mycobacterium tuberculosis e.g. RV2449C|O53176|MTV008.05C
HYPOTHETICAL 44.4 KDA PROTEIN (419 aa), FASTA scores: opt:
1835, E(): 7e-110, (67.55% identity in 419 aa overlap);
etc. Protein product from Mb2977 detected using shotgun
mass spectrometry and SWATH mass spectrometry. Mb2977
found to be expressed during exponential growth in
Sauton's minimal media by RNA-sequencing (TPM > 20)."
/db_xref="GOA:Q7TXK2"
/db_xref="InterPro:IPR005097"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:Q7TXK2"
/experiment="experimental evidence, no additional details
recorded"
BEGIN
1 MSPAEREFDI VLYGATGFSG KLTAEHLAHS GSTARIALAG RSSERLRGVR MMLGPNAADW
61 PLILADASQP LTLEAMAARA QVVLTTVGPY TRYGLPLVAA CAKAGTDYAD LTGELMFCRN
121 SIDLYHKQAA DTGARIILAC GFDSIPSDLN VYQLYRRSVE DGTGELCDTD LVLRSFSQRW
181 VSGGSVATYS EAMRTASSDP EARRLVTDPY TLTTDRGAEP ELGAQPDFLR RPGRDLAPEL
241 AGFWTGGFVQ APFNTRIVRR SNALQEWAYG RRFRYSETMS LGKSMAAPIL AAAVTGTVAG
301 TIGLGNKYFD RLPRRLVERV TPKPGTGPSR KTQERGHYTF ETYTTTTTGA RYRATFAHNV
361 DAYKSTAVLL AQSGLALALD RDRLAELRGV LTPAAAMGDA LLARLPGAGV VMGTTRLS
//