LOCUS SIU01597.1 381 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE OXIDOREDUCTASE protein. ACCESSION LT708304-3011 PROTEIN_ID SIU01597.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2975C" /note="Mb2975c, -, len: 381 aa. Equivalent to Rv2951c, len: 381 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 381 aa overlap). Possible oxidoreductase (EC 1.-.-.-), equivalent to Q9CD85 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (382 aa), FASTA scores: opt: 2225, E(): 7.6e-134, (84.8% identity in 382 aa overlap); and similar to O30260 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium leprae (363 aa), FASTA scores: opt: 652, E(): 6.1e-34, (32.55% identity in 344 aa overlap). Also similar to various oxidoreductases e.g. O29071|AF1196 N5,N10-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE from Archaeoglobus fulgidus (348 aa), FASTA scores: opt: 381, E(): 9.7e-17, (27.7% identity in 354 aa overlap); Q58929|MER|MJ1534 F420-DEPENDENT METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE (EC 1.5.99.-) from Methanococcus jannaschii (331 aa), FASTA scores: opt: 372, E(): 3.5e-16, (30.85% identity in 295 aa overlap); Q9UXP0 PUTATIVE F420-DEPENDENT N5,N10-METHYLENE-TETRAHYDROMETHANOPTERIN REDUCTASE from Methanolobus tindarius (326 aa), FASTA scores: opt: 343, E(): 2.4e-14, (27.4% identity in 314 aa overlap); etc. Protein product from Mb2975c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2975c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:Q7TXK4" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR036661" /db_xref="UniProtKB/Swiss-Prot:Q7TXK4" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MGGLRFGFVD ALVHSRLPPT LPARSSMAAA TVMGADSYWV GDHLNALVPR SIATSEYLGI 61 AAKFVPKIDA NYEPWTMLGN LAFGLPSRLR LGVCVTDAGR RNPAVTAQAA ATLHLLTRGR 121 AILGIGVGER EGNEPYGVEW TKPVARFEEA LATIRALWNS NGELISRESP YFPLHNALFD 181 LPPYRGKWPE IWVAAHGPRM LRATGRYADA WIPIVVVRPS DYSRALEAVR SAASDAGRDP 241 MSITPAAVRG IITGRNRDDV EEALESVVVK MTALGVPGEA WARHGVEHPM GADFSGVQDI 301 IPQTMDKQTV LSYAAKVPAA LMKEVVFSGT PDEVIDQVAE WRDHGLRYVV LINGSLVNPS 361 LRKTVTAVLP HAKVLRGLKK L //