LOCUS       SIU01597.1               381 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            OXIDOREDUCTASE protein.
ACCESSION   LT708304-3011
PROTEIN_ID  SIU01597.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2975C"
                     /note="Mb2975c, -, len: 381 aa. Equivalent to Rv2951c,
                     len: 381 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 381 aa overlap). Possible
                     oxidoreductase (EC 1.-.-.-), equivalent to Q9CD85 PUTATIVE
                     OXIDOREDUCTASE from Mycobacterium leprae (382 aa), FASTA
                     scores: opt: 2225, E(): 7.6e-134, (84.8% identity in 382
                     aa overlap); and similar to O30260 CONSERVED HYPOTHETICAL
                     PROTEIN from Mycobacterium leprae (363 aa), FASTA scores:
                     opt: 652, E(): 6.1e-34, (32.55% identity in 344 aa
                     overlap). Also similar to various oxidoreductases e.g.
                     O29071|AF1196 N5,N10-METHYLENETETRAHYDROMETHANOPTERIN
                     REDUCTASE from Archaeoglobus fulgidus (348 aa), FASTA
                     scores: opt: 381, E(): 9.7e-17, (27.7% identity in 354 aa
                     overlap); Q58929|MER|MJ1534 F420-DEPENDENT
                     METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE (EC 1.5.99.-)
                     from Methanococcus jannaschii (331 aa), FASTA scores: opt:
                     372, E(): 3.5e-16, (30.85% identity in 295 aa overlap);
                     Q9UXP0 PUTATIVE F420-DEPENDENT
                     N5,N10-METHYLENE-TETRAHYDROMETHANOPTERIN REDUCTASE from
                     Methanolobus tindarius (326 aa), FASTA scores: opt: 343,
                     E(): 2.4e-14, (27.4% identity in 314 aa overlap); etc.
                     Protein product from Mb2975c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb2975c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:Q7TXK4"
                     /db_xref="InterPro:IPR011251"
                     /db_xref="InterPro:IPR036661"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TXK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MGGLRFGFVD ALVHSRLPPT LPARSSMAAA TVMGADSYWV GDHLNALVPR SIATSEYLGI
       61 AAKFVPKIDA NYEPWTMLGN LAFGLPSRLR LGVCVTDAGR RNPAVTAQAA ATLHLLTRGR
      121 AILGIGVGER EGNEPYGVEW TKPVARFEEA LATIRALWNS NGELISRESP YFPLHNALFD
      181 LPPYRGKWPE IWVAAHGPRM LRATGRYADA WIPIVVVRPS DYSRALEAVR SAASDAGRDP
      241 MSITPAAVRG IITGRNRDDV EEALESVVVK MTALGVPGEA WARHGVEHPM GADFSGVQDI
      301 IPQTMDKQTV LSYAAKVPAA LMKEVVFSGT PDEVIDQVAE WRDHGLRYVV LINGSLVNPS
      361 LRKTVTAVLP HAKVLRGLKK L
//