LOCUS       SIU01588.1               920 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 CONSERVED
            TRANSMEMBRANE TRANSPORT PROTEIN MMPL7 protein.
ACCESSION   LT708304-3002
PROTEIN_ID  SIU01588.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mmpL7"
                     /locus_tag="BQ2027_MB2967"
                     /note="Mb2967, mmpL7, len: 920 aa. Equivalent to Rv2942,
                     len: 920 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 920 aa overlap). mmpL7, conserved
                     transmembrane transport protein (see citations below),
                     member of RND superfamily, highly similar to Q9XB10
                     HYPOTHETICAL 99.5 KDA PROTEIN from Mycobacterium bovis BCG
                     (945 aa), FASTA scores: opt: 488, E(): 4.9e-20, (29.5%
                     identity in 918 aa overlap); and to others from
                     Mycobacteria e.g. O53735|MML4_MYCTU from Mycobacterium
                     tuberculosis (945 aa), FASTA scores: opt: 481, E():
                     1.2e-19, (25.9% identity in 922 aa overlap); etc. Also
                     similar to other membrane proteins e.g.
                     O54101|MMLB_STRCO|SC10A5.10c PUTATIVE MEMBRANE PROTEIN
                     from Streptomyces coelicolor (847 aa), FASTA scores: opt:
                     256, E(): 7.2e-07, (25.15% identity in 545 aa overlap);
                     etc. Contains PS00639 Eukaryotic thiol (cysteine)
                     proteases histidine active site, PS00079 Multicopper
                     oxidases signature 1, and PS00044 Bacterial regulatory
                     proteins, lysR family signature. BELONGS TO THE MMPL
                     FAMILY. Note that Rv2941|fadD28 and Rv2942|mmpL7 are
                     transcriptionally coupled (proven experimentaly). Protein
                     product from Mb2967 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb2967 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P65371"
                     /db_xref="InterPro:IPR004869"
                     /db_xref="UniProtKB/Swiss-Prot:P65371"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MPSPAGRLHR IRYIRLKKSS PDCRATITSG SADGQRRSPR LTNLLVVAAW VAAAVIANLL
       61 LTFTQAEPHD TSPALLPQDA KTAAATSRIA QAFPGTGSNA IAYLVVEGGS TLEPQDQPYY
      121 DAAVGALRAD TRHVGSVLDW WSDPVTAPLG TSPDGRSATA MVWLRGEAGT TQAAESLDAV
      181 RSVLRQLPPS EGLRASIVVP AITNDMPMQI TAWQSATIVT VAAVIAVLLL LRARLSVRAA
      241 AIVLLTADLS LAVAWPLAAV VRGHDWGTDS VFSWTLAAVL TIGTITAATM LAARLGSDAG
      301 HSAAPTYRDS LPAFALPGAC VAIFTGPLLL ARTPALHGVG TAGLGVFVAL AASLTVLPAL
      361 IALAGASRQL PAPTTGAGWT GRLSLPVSSA SALGTAAVLA ICMLPIIGMR WGVAENPTRQ
      421 GGAQVLPGNA LPDVVVIKSA RDLRDPAALI AINQVSHRLV EVPGVRKVES AAWPAGVPWT
      481 DASLSSAAGR LADQLGQQAG SFVPAVTAIK SMKSIIEQMS GAVDQLDSTV NVTLAGARQA
      541 QQYLDPMLAA ARNLKNKTTE LSEYLETIHT WIVGFTNCPD DVLCTAMRKV IEPYDIVVTG
      601 MNELSTGADR ISAISTQTMS ALSSAPRMVA QMRSALAQVR SFVPKLETTI QDAMPQIAQA
      661 SAMLKNLSAD FADTGEGGFH LSRKDLADPS YRHVRESMFS SDGTATRLFL YSDGQLDLAA
      721 AARAQQLEIA AGKAMKYGSL VDSQVTVGGA AQIAAAVRDA LIHDAVLLAV ILLTVVALAS
      781 MWRGAVHGAA VGVGVLASYL AALGVSIALW QHLLDRELNA LVPLVSFAVL ASCGVPYLVA
      841 GIKAGRIADE ATGARSKGAV SGRGAVAPLA ALGGVFGAGL VLVSGGSFSV LSQIGTVVVL
      901 GLGVLITVQR AWLPTTPGRR
//