LOCUS       SIU01570.1               289 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE FPG (FAPY-DNA GLYCOSYLASE)
            protein.
ACCESSION   LT708304-2984
PROTEIN_ID  SIU01570.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fpg"
                     /locus_tag="BQ2027_MB2949C"
                     /note="Mb2949c, fpg, len: 289 aa. Equivalent to Rv2924c,
                     len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 289 aa overlap). Probable fpg
                     (alternate gene name: mutM), formamidopyrimidine-DNA
                     glycosylase (EC 3.2.2.23), equivalent to O69470|FPG_MYCLE
                     FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Mycobacterium
                     leprae (282 aa), FASTA scores: opt: 1563, E(): 1.3e-96,
                     (80.6% identity in 289 aa overlap). Also highly similar to
                     other formamidopyrimidine-DNA glycosylases e.g.
                     Q9ZBQ6|FPG_STRCO from Streptomyces coelicolor (286 aa),
                     FASTA scores: opt: 1047, E(): 2.9e-62, (57.55% identity in
                     292 aa overlap); P95744|FPG_SYNEN from Synechococcus
                     elongatus naegeli (284 aa), FASTA scores: opt: 569, E():
                     1.9e-30, (37.95% identity in 290 aa overlap);
                     P05523|FPG_ECOLI|MUTM|FPG|B3635 from Escherichia coli
                     strain K12 (269 aa), FASTA scores: opt: 424, E(): 8.2e-21,
                     (33.9% identity in 289 aa overlap); etc. BELONGS TO THE
                     FPG FAMILY. COFACTOR: BINDS 1 ZINC ION. Mb2949c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P64151"
                     /db_xref="InterPro:IPR000214"
                     /db_xref="InterPro:IPR010663"
                     /db_xref="InterPro:IPR010979"
                     /db_xref="InterPro:IPR012319"
                     /db_xref="InterPro:IPR015886"
                     /db_xref="InterPro:IPR015887"
                     /db_xref="InterPro:IPR020629"
                     /db_xref="InterPro:IPR035937"
                     /db_xref="UniProtKB/Swiss-Prot:P64151"
BEGIN
        1 MPELPEVEVV RRGLQAHVTG RTITEVRVHH PRAVRRHDAG PADLTARLRG ARINGTDRRG
       61 KYLWLTLNTA GVHRPTDTAL VVHLGMSGQM LLGAVPCAAH VRISALLDDG TVLSFADQRT
      121 FGGWLLADLV TVDGSVVPVP VAHLARDPLD PRFDCDAVVK VLRRKHSELK RQLLDQRVVS
      181 GIGNIYADEA LWRAKVNGAH VAATLRCRRL GAVLHAAADV MREALAKGGT SFDSLYVNVN
      241 GESGYFERSL DAYGREGENC RRCGAVIRRE RFMNRSSFYC PRCQPRPRK
//