LOCUS SIU01538.1 325 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE OXIDOREDUCTASE protein. ACCESSION LT708304-2952 PROTEIN_ID SIU01538.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2917" /note="Mb2917, -, len: 325 aa. Equivalent to Rv2893, len: 325 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 325 aa overlap). Possible oxidoreductase (EC 1.-.-.-), showing similarity with various proteins and/or oxidoreductases e.g. Q9AE05|RIF11 eleventh protein in the rif biosynthetic gene cluster from Amycolatopsis mediterranei (Nocardia mediterranei) (294 aa), FASTA scores: opt: 270, E(): 4.8e-10, (34.5% identity in 313 aa overlap); O52567 REDUCTASE from Amycolatopsis mediterranei (Nocardia mediterranei) (153 aa), FASTA scores: opt: 251, E(): 5e-09, (42.4% identity in 125 aa overlap); Q58929|MER|MJ1534 F420-DEPENDENT METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE (EC 1.5.99.-) from Methanococcus jannaschii (331 aa), FASTA scores: opt: 249, E(): 1.2e-08, (29.7% identity in 283 aa overlap); etc. Also some similarity with others proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. P71844|Rv0791c|MTCY369.35c PUTATIVE OXIDOREDUCTASE (347 aa), FASTA scores: opt: 264, E(): 1.3e-09, (29.05% identity in 272 aa overlap); and P96809|Rv0132|MTCI5.06c PUTATIVE OXIDOREDUCTASE (360 aa), FASTA scores: opt: 260, E(): 2.4e-09, (33.05% identity in 239 aa overlap). Protein product from Mb2917 detected using shotgun mass spectrometry and SWATH mass spectrometry." /db_xref="GOA:A0A1R3Y2X5" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019923" /db_xref="InterPro:IPR036661" /db_xref="UniProtKB/TrEMBL:A0A1R3Y2X5" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MTVASTAHHT RRLRFGLAAP LPRAGTQMRA FAQAVEAAGF DVLAFPDHLV PSVSPFAGAT 61 AAAMATQRLH TGTLVLNNDF RHPVDTAREA AGVATLAEGR FELGLGAGHR RSEYDAAGIT 121 FDSGATRVAR LIESAHLIRA LLDAEPVDFD GQHYRVHAEA GSLVAPPKVR VPLLVGGNGT 181 EVLRLGGRIA DIVGLAGISH NRDATQVRFT HFDADGLADR IAVVRHAAGD RFEAIELNAL 241 IQAVVCTNDR NAAAAELAAT LGGITPEQVL ESPFLLLGTH EQMAEALAAR QRRFGVSYWT 301 VFDEWAGRAS AMRDIAEVIA LLRYG //