LOCUS       SIU01526.1               306 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            INTEGRAL MEMBRANE PHOSPHATIDATE CYTIDYLYLTRANSFERASE CDSA
            (CDP-DIGLYCERIDE SYNTHETASE) (CDP-DIGLYCERIDE PYROPHOSPHORYLASE)
            (CDP-DIACYLGLYCEROL SYNTHASE) (CDS) (CTP:PHOSPHATIDATE
            CYTIDYLYLTRANSFERASE) (CDP-DAG SYNTHASE) (CDP-DG SYNTHETASE)
            protein.
ACCESSION   LT708304-2940
PROTEIN_ID  SIU01526.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="cdsA"
                     /locus_tag="BQ2027_MB2905C"
                     /note="Mb2905c, cdsA, len: 306 aa. Equivalent to Rv2881c,
                     len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 306 aa overlap). Probable cdsA,
                     phosphatidate cytidylyltransferase (EC 2.7.7.41), integral
                     membrane protein, equivalent to Q9CBU1|CDSA_MYCLE|ML1589
                     PHOSPHATIDATE CYTIDYLYLTRANSFERASE from Mycobacterium
                     leprae (312 aa), FASTA scores: opt: 1470, E(): 1.1e-84,
                     (70.3% identity in 313 aa overlap). Also similar to others
                     e.g. Q9KPV7|VC2255 from Vibrio cholerae (280 aa), FASTA
                     scores: opt: 383, E(): 1.1e-16, (29.3% identity in 280 aa
                     overlap); Q9CDT2|CDSA from Lactococcus lactis (subsp.
                     lactis) (Streptococcus lactis) (267 aa), FASTA scores:
                     opt: 361, E(): 2.6e-15, (29.05% identity in 265 aa
                     overlap); P06466|CDSA_ECOLI|CDS|B0175|Z0186|ECS0177 from
                     Escherichia coli strains K12 and O157:H7 (249 aa), FASTA
                     scores: opt: 352, E(): 9.2e-15, (40.4% identity in 156 aa
                     overlap); etc. Contains PS00017 ATP/GTP-binding site motif
                     A (P-loop). BELONGS TO THE CDS FAMILY. Protein product
                     from Mb2905c detected using shotgun mass spectrometry.
                     Mb2905c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:P63759"
                     /db_xref="InterPro:IPR000374"
                     /db_xref="UniProtKB/Swiss-Prot:P63759"
BEGIN
        1 MTTNDAGTGN PAEQPARGAK QQPATETSRA GRDLRAAIVV GLSIGLVLIA VLVFVPRVWV
       61 AIVAVATLVA THEVVRRLRE AGYLIPVIPL LIGGQAAVWL TWPFGAVGAL AGFGGMVVVC
      121 MIWRLFMQDS VTRPTTGGAP SPGNYLSDVS ATVFLAVWVP LFCSFGAMLV YPENGSGWVF
      181 CMMIAVIASD VGGYAVGVLF GKHPMVPTIS PKKSWEGFAG SLVCGITATI ITATFLVGKT
      241 PWIGALLGVL FVLTTALGDL VESQVKRDLG IKDMGRLLPG HGGLMDRLDG ILPSAVAAWI
      301 VLTLLP
//