LOCUS       SIU01524.1               173 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 soluble
            secreted antigen mpt53 precursor protein.
ACCESSION   LT708304-2938
PROTEIN_ID  SIU01524.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mpt53"
                     /locus_tag="BQ2027_MB2903C"
                     /standard_name="mpt53"
                     /note="Mb2903c, mpb53, len: 173 aa. Equivalent to Rv2878c,
                     len: 173 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 173 aa overlap). mpt53, secreted
                     protein (contains N-terminal signal sequence) (see
                     citations below). Shows some similarity with several
                     disulfide bond interchange proteins e.g. P43787|THIX_HAEIN
                     THIOREDOXIN-LIKE PROTEIN HI1115 from Haemophilus
                     influenzae (167 aa), FASTA scores: opt: 200, E(): 1.4e-06,
                     (28.9% identity in 135 aa overlap); P52237|TIPB_PSEFL
                     THIOL:DISULFIDE INTERCHANGE PROTEIN TIPB PRECURSOR
                     (CYTOCHROME C BIOGENESIS PROTEIN TIPB) (178 aa), FASTA
                     scores: opt: 184, E(): 1.8e-05, (26.3% identity in 171 aa
                     overlap); etc. Also highly similar to
                     O53924|DSBF|Rv1677|MTV047.12 PUTATIVE LIPOPROTEIN from
                     Mycobacterium tuberculosis (182 aa), FASTA scores: opt:
                     482, E(): 5.7e-26, (52.8% identity in 142 aa overlap).
                     COULD BE BELONG TO THE THIOREDOXIN FAMILY. Note that also
                     previously known as dsbE. Protein product from Mb2903c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb2903c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A619"
                     /db_xref="InterPro:IPR000866"
                     /db_xref="InterPro:IPR013766"
                     /db_xref="InterPro:IPR036249"
                     /db_xref="UniProtKB/Swiss-Prot:P0A619"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MSLRLVSPIK AFADGIVAVA IAVVLMFGLA NTPRAVAADE RLQFTATTLS GAPFDGASLQ
       61 GKPAVLWFWT PWCPFCNAEA PSLSQVAAAN PAVTFVGIAT RADVGAMQSF VSKYNLNFTN
      121 LNDADGVIWA RYNVPWQPAF VFYRADGTST FVNNPTAAMS QDELSGRVAA LTS
//