LOCUS       SIU01516.1               413 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP
            REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE)
            protein.
ACCESSION   LT708304-2930
PROTEIN_ID  SIU01516.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="dxr"
                     /locus_tag="BQ2027_MB2895C"
                     /note="Mb2895c, dxr, len: 413 aa. Equivalent to Rv2870c,
                     len: 413 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 413 aa overlap). Probable dxr,
                     1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC
                     1.1.1.-), equivalent to Q9CBU3|DXR|ML1583
                     1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE from
                     Mycobacterium leprae (406 aa), FASTA scores: opt: 2145,
                     E(): 1e-124, (84.05% identity in 395 aa overlap). Also
                     highly similar to others e.g. Q9AJD7|DXR from
                     Kitasatospora griseola (Streptomyces griseolosporeus) (386
                     aa), FASTA scores: opt: 1176, E(): 5.2e-65, (56.45%
                     identity in 388 aa overlap); Q9KYS1|DXR_STRCO|SC5H4.18
                     from Streptomyces coelicolor (401 aa), FASTA scores: opt:
                     1079, E(): 5.1e-59, (52.25% identity in 396 aa overlap);
                     P45568|DXR|B0173 from Escherichia coli strain K12 (398
                     aa), FASTA scores: opt: 120, E(): 0.032, (52.9% identity
                     in 34 aa overlap); etc. Contains PS00133 Zinc
                     carboxypeptidases, zinc-binding region 2 signature.
                     BELONGS TO THE DXR FAMILY. N-terminus shortened since
                     first submission. Protein product from Mb2895c detected
                     using SWATH mass spectrometry. Mb2895c found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P64013"
                     /db_xref="InterPro:IPR003821"
                     /db_xref="InterPro:IPR013512"
                     /db_xref="InterPro:IPR013644"
                     /db_xref="InterPro:IPR026877"
                     /db_xref="InterPro:IPR036169"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/Swiss-Prot:P64013"
BEGIN
        1 MTNSTDGRAD GRLRVVVLGS TGSIGTQALQ VIADNPDRFE VVGLAAGGAH LDTLLRQRAQ
       61 TGVTNIAVAD EHAAQRVGDI PYHGSDAATR LVEQTEADVV LNALVGALGL RPTLAALKTG
      121 ARLALANKES LVAGGSLVLR AARPGQIVPV DSEHSALAQC LRGGTPDEVA KLVLTASGGP
      181 FRGWSAADLE HVTPEQAGAH PTWSMGPMNT LNSASLVNKG LEVIETHLLF GIPYDRIDVV
      241 VHPQSIIHSM VTFIDGSTIA QASPPDMKLP ISLALGWPRR VSGAAAACDF HTASSWEFEP
      301 LDTDVFPAVE LARQAGVAGG CMTAVYNAAN EEAAAAFLAG RIGFPAIVGI IADVLHAADQ
      361 WAVEPATVDD VLDAQRWARE RAQRAVSGMA SVAIASTAKP GAAGRHASTL ERS
//