LOCUS       SIU01503.1               455 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ALDEHYDE DEHYDROGENASE ALDC protein.
ACCESSION   LT708304-2917
PROTEIN_ID  SIU01503.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="aldC"
                     /locus_tag="BQ2027_MB2883C"
                     /note="Mb2883c, aldC, len: 455 aa. Equivalent to Rv2858c,
                     len: 455 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 455 aa overlap). Probable aldC,
                     aldehyde dehydrogenase (EC 1.2.1.3), similar to many e.g.
                     O88069|SCI35.34c PUTATIVE ALDEHYDE DEHYDROGENASE from
                     Streptomyces coelicolor (483 aa), FASTA scores: opt: 1872,
                     E(): 6.4e-109, (64.5% identity in 448 aa overlap);
                     Q9FAB1|ALDH|BT-ALDH ALDEHYDE DEHYDROGENASE from Bacillus
                     thermoleovorans (497 aa), FASTA scores: opt: 1157, E():
                     2.1e-64, (44.3% identity in 458 aa overlap); O33455|CYMC
                     P-CUMIC ALDEHYDE DEHYDROGENASE from Pseudomonas putida
                     (494 aa), FASTA scores: opt: 1149, E(): 6.5e-64, (43.15%
                     identity in 452 aa overlap);
                     P40047|DHA5_YEAST|ALD5|ALDH5|ALD3|YER073W ALDEHYDE
                     DEHYDROGENASE from Saccharomyces cerevisiae (Baker's
                     yeast) (519 aa), FASTA scores: opt: 1091, E(): 2.7e-60,
                     (38.55% identity in 459 aa overlap);
                     P80668|FEAB_ECOLI|PADA|MAOB|B1385 PHENYLACETALDEHYDE
                     DEHYDROGENASE (EC 1.2.1.39) from Escherichia coli strain
                     K12 (499 aa), FASTA scores: opt: 1074, E(): 3e-59, (42.2%
                     identity in 462 aa overlap); etc. Also similar to many M.
                     tuberculosis dehydrogenases e.g. P71823|Rv0768|MTCY369.13
                     (489 aa), FASTA score: (38.1% identity in 467 aa overlap).
                     Contains PS00687 Aldehyde dehydrogenases glutamic acid
                     active site and PS00070 Aldehyde dehydrogenases cysteine
                     active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES
                     FAMILY. Protein product from Mb2883c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb2883c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y2F3"
                     /db_xref="InterPro:IPR015590"
                     /db_xref="InterPro:IPR016160"
                     /db_xref="InterPro:IPR016161"
                     /db_xref="InterPro:IPR016162"
                     /db_xref="InterPro:IPR016163"
                     /db_xref="InterPro:IPR029510"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y2F3"
BEGIN
        1 MSTTQLINPA TEEVLASVDH TDANAVDDAV QRARAAQRRW ARLAPAQRAA GLRAFAAAVQ
       61 AHLDELAALE VANSGHPIVS AEWEAGHVRD VLAFYAASPE RLSGRQIPVA GGVDVTFNEP
      121 MGVVGVITPW NFPMVIASWA IAPALAAGNA VLVKPAELTP LTTMRLGELA VEAGLDEDLL
      181 QVLPGKGTVV GERFVTHPDI RKIVFTGSTE VGKRVMAGAA AQVKRVTLEL GGKSANIVFH
      241 DCDLERAATT APAGVFDNAG QDCCARSRIL VQRSVYDRFM ELLEPAVHSI VVGDPGSRAT
      301 EMGPLVSRAH RDKVAGYVPD DAPVAFRGTA PAGRGFWFPP TVLTPKRGDR TVTDEIFGPV
      361 VVVLTFDDEA DAISLANDTA YGLSGSIWTD DLSRALRVAR AVESGNLSVN SHSSVRFNTP
      421 FGGFKQSGVG RELGPDAPLQ FTETKNVFIA VGEEM
//