LOCUS       SIU01502.1               258 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE protein.
ACCESSION   LT708304-2916
PROTEIN_ID  SIU01502.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2882C"
                     /note="Mb2882c, -, len: 258 aa. Equivalent to Rv2857c,
                     len: 258 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 258 aa overlap). Probable short-chain
                     dehydrogenase/reductase (EC 1.-.-.-), highly similar to
                     various dehydrogenases e.g. O88068|SCI35.33c PROBABLE
                     DEHYDROGENASE (SDR FAMILY) from Streptomyces coelicolor
                     (260 aa), FASTA scores: opt: 1208, E(): 2e-68, (72.35%
                     identity in 253 aa overlap); Q9I376|PA1649 from
                     Pseudomonas aeruginosa PROBABLE SHORT-CHAIN DEHYDROGENASE
                     (253 aa), FASTA scores: opt: 569, E(): 2.1e-28, (39.2%
                     identity in 255 aa overlap); Q9EX74|MLHA SDR-LIKE ENZYME
                     from Rhodococcus erythropolis (246 aa), FASTA scores: opt:
                     567, E(): 2.8e-28, (41.15% identity in 248 aa overlap);
                     etc. Also similar to many Mycobacterium tuberculosis
                     dehydrogenases e.g. FABG3|Rv2002|MT2058|MTCY39.16c
                     PUTATIVE OXIDOREDUCTASE (260 aa), FASTA score: (38.3%
                     identity in 248 aa overlap). BELONGS TO THE SHORT-CHAIN
                     DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Protein product
                     from Mb2882c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb2882c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y2E1"
BEGIN
        1 MMDLSQRLAG RVAVITGGGS GIGLAAGRRM RAEGATIVVG DVDVEAGGAA ADELSGLFVP
       61 TDVCDEDAVN GLFDGAAETY GRIDIAFNNA GISPPEDNLI ENTELAAWQR VQDVNLKSVY
      121 LCCRAALRHM VLAGKGSIVN TASFVAVMGS ATSQISYTAS KGGVLAMSRE LGVQFARQGI
      181 RVNALCPGPV NTPLLQELFA KNPERAARRM VHVPLGRFAE PDEIAAAVAF LASDDASFIT
      241 ASTFLVDGGI SSAYVTPL
//