LOCUS SIU01502.1 258 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE protein. ACCESSION LT708304-2916 PROTEIN_ID SIU01502.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2882C" /note="Mb2882c, -, len: 258 aa. Equivalent to Rv2857c, len: 258 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 258 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to various dehydrogenases e.g. O88068|SCI35.33c PROBABLE DEHYDROGENASE (SDR FAMILY) from Streptomyces coelicolor (260 aa), FASTA scores: opt: 1208, E(): 2e-68, (72.35% identity in 253 aa overlap); Q9I376|PA1649 from Pseudomonas aeruginosa PROBABLE SHORT-CHAIN DEHYDROGENASE (253 aa), FASTA scores: opt: 569, E(): 2.1e-28, (39.2% identity in 255 aa overlap); Q9EX74|MLHA SDR-LIKE ENZYME from Rhodococcus erythropolis (246 aa), FASTA scores: opt: 567, E(): 2.8e-28, (41.15% identity in 248 aa overlap); etc. Also similar to many Mycobacterium tuberculosis dehydrogenases e.g. FABG3|Rv2002|MT2058|MTCY39.16c PUTATIVE OXIDOREDUCTASE (260 aa), FASTA score: (38.3% identity in 248 aa overlap). BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Protein product from Mb2882c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2882c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="UniProtKB/TrEMBL:A0A1R3Y2E1" BEGIN 1 MMDLSQRLAG RVAVITGGGS GIGLAAGRRM RAEGATIVVG DVDVEAGGAA ADELSGLFVP 61 TDVCDEDAVN GLFDGAAETY GRIDIAFNNA GISPPEDNLI ENTELAAWQR VQDVNLKSVY 121 LCCRAALRHM VLAGKGSIVN TASFVAVMGS ATSQISYTAS KGGVLAMSRE LGVQFARQGI 181 RVNALCPGPV NTPLLQELFA KNPERAARRM VHVPLGRFAE PDEIAAAVAF LASDDASFIT 241 ASTFLVDGGI SSAYVTPL //