LOCUS SIU01494.1 207 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE COB(I)ALAMIN ADENOSYLTRANSFERASE COBO (CORRINOID ADENOSYLTRANSFERASE ) (CORRINOID ADOTRANSFERASE ACTIVITY) protein. ACCESSION LT708304-2908 PROTEIN_ID SIU01494.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="cobO" /locus_tag="BQ2027_MB2874C" /note="Mb2874c, cobO, len: 207 aa. Equivalent to Rv2849c, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 207 aa overlap). Probable cobO, cob(I)alamin adenosyltransferase (EC 2.5.1.17), highly similar to Q9RJ17|COBO from Streptomyces coelicolor (199 aa), FASTA scores: opt: 918, E(): 1.1e-55, (64.75% identity in 207 aa overlap); and similar to others e.g. O30785|COBO from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (212 aa), FASTA scores: opt: 329, E(): 2.8e-15, (44.3% identity in 185 aa overlap); P29930|COBO_PSEDE from Pseudomonas denitrificans (213 aa), FASTA scores: opt: 280, E(): 6.5e-12, (38.9% identity in 185 aa overlap); P31570|BTUR_SALTY|COBA from Salmonella typhimurium (196 aa), FASTA scores: opt: 278, E(): 8.4e-12, (39.8% identity in 196 aa overlap); etc. COFACTOR: MANGANESE. Note that previously known as cobA. Protein product from Mb2874c detected using SWATH mass spectrometry. Mb2874c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y2E7" /db_xref="InterPro:IPR003724" /db_xref="InterPro:IPR027417" /db_xref="UniProtKB/TrEMBL:A0A1R3Y2E7" BEGIN 1 MPQGNPLAVP NDGLTTRARR NMPILAVHTG EGKGKSTAAF GMALRAWNAG LDIAVFQFVK 61 SAKWKVGEEA AFRQLGRLHD QHGIGGAVEW HKMGAGWSWT RTSRKAGTDV DRAAAAADGC 121 AEIALRLATQ RHDFYLLDEF TYPLKWGWLD VDEVVDVLRA RPGHQHVVIT GRDAPQRLVA 181 AADLVTEMTK VKHPMDAGRK GQKGIEW //