LOCUS       SIU01494.1               207 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            COB(I)ALAMIN ADENOSYLTRANSFERASE COBO (CORRINOID ADENOSYLTRANSFERASE
            ) (CORRINOID ADOTRANSFERASE ACTIVITY) protein.
ACCESSION   LT708304-2908
PROTEIN_ID  SIU01494.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="cobO"
                     /locus_tag="BQ2027_MB2874C"
                     /note="Mb2874c, cobO, len: 207 aa. Equivalent to Rv2849c,
                     len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.5% identity in 207 aa overlap). Probable cobO,
                     cob(I)alamin adenosyltransferase (EC 2.5.1.17), highly
                     similar to Q9RJ17|COBO from Streptomyces coelicolor (199
                     aa), FASTA scores: opt: 918, E(): 1.1e-55, (64.75%
                     identity in 207 aa overlap); and similar to others e.g.
                     O30785|COBO from Rhodobacter capsulatus (Rhodopseudomonas
                     capsulata) (212 aa), FASTA scores: opt: 329, E(): 2.8e-15,
                     (44.3% identity in 185 aa overlap); P29930|COBO_PSEDE from
                     Pseudomonas denitrificans (213 aa), FASTA scores: opt:
                     280, E(): 6.5e-12, (38.9% identity in 185 aa overlap);
                     P31570|BTUR_SALTY|COBA from Salmonella typhimurium (196
                     aa), FASTA scores: opt: 278, E(): 8.4e-12, (39.8% identity
                     in 196 aa overlap); etc. COFACTOR: MANGANESE. Note that
                     previously known as cobA. Protein product from Mb2874c
                     detected using SWATH mass spectrometry. Mb2874c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y2E7"
                     /db_xref="InterPro:IPR003724"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y2E7"
BEGIN
        1 MPQGNPLAVP NDGLTTRARR NMPILAVHTG EGKGKSTAAF GMALRAWNAG LDIAVFQFVK
       61 SAKWKVGEEA AFRQLGRLHD QHGIGGAVEW HKMGAGWSWT RTSRKAGTDV DRAAAAADGC
      121 AEIALRLATQ RHDFYLLDEF TYPLKWGWLD VDEVVDVLRA RPGHQHVVIT GRDAPQRLVA
      181 AADLVTEMTK VKHPMDAGRK GQKGIEW
//