LOCUS       SIU01484.1               900 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            TRANSLATION INITIATION FACTOR IF-2 INFB protein.
ACCESSION   LT708304-2898
PROTEIN_ID  SIU01484.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="infB"
                     /locus_tag="BQ2027_MB2864C"
                     /note="Mb2864c, infB, len: 900 aa. Equivalent to Rv2839c,
                     len: 900 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 900 aa overlap). Probable infB,
                     translation initiation factor IF-2, highly similar, but in
                     part, to Q9Z5I9|IF2_MYCLE|ML1556|MLCB596.14 TRANSLATION
                     INITIATION FACTOR IF-2 from Mycobacterium leprae (924 aa),
                     FASTA scores: opt: 4548, E(): 2.4e-132, (83.6% identity in
                     933 aa overlap). Also similar in part to others e.g.
                     Q9K3E2|SC5H4.30 from Streptomyces coelicolor (835 aa),
                     FASTA scores: opt: 2559, E(): 1.3e-71, (59.9% identity in
                     833 aa overlap); P17889|IF2_BACSU|INFB from Bacillus
                     subtilis (716 aa), FASTA scores: opt: 1782, E(): 6.6e-48,
                     (46.65% identity in 686 aa overlap);
                     P02995|IF2_ECOLI|INFB|SSYG|B3168|Z4529|ECS4049 from
                     Escherichia coli strains O157:H7 and K12 (890 aa), FASTA
                     scores: opt: 1708, E(): 1.3e-45, (46.2% identity in 662 aa
                     overlap); etc. Contains PS00017 ATP/GTP-binding site motif
                     A (P-loop). BELONGS TO THE IF-2 FAMILY. Protein product
                     from Mb2864c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb2864c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P65132"
                     /db_xref="InterPro:IPR000178"
                     /db_xref="InterPro:IPR000795"
                     /db_xref="InterPro:IPR005225"
                     /db_xref="InterPro:IPR006847"
                     /db_xref="InterPro:IPR009000"
                     /db_xref="InterPro:IPR015760"
                     /db_xref="InterPro:IPR023115"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR036925"
                     /db_xref="UniProtKB/Swiss-Prot:P65132"
BEGIN
        1 MAAGKARVHE LAKELGVTSK EVLARLSEQG EFVKSASSTV EAPVARRLRE SFGGSKPAPA
       61 KGTAKSPGKG PDKSLDKALD AAIDMAAGNG KATAAPAKAA DSGGAAIVSP TTPAAPEPPT
      121 AVPPSPQAPH PGMAPGARPG PVPKPGIRTP RVGNNPFSSA QPADRPIPRP PAPRPGTARP
      181 GVPRPGASPG SMPPRPGGAV GGARPPRPGA PRPGGRPGAP GAGRSDAGGG NYRGGGVGAA
      241 PGTGFRGRPG GGGGGRPGQR GGAAGAFGRP GGAPRRGRKS KRQKRQEYDS MQAPVVGGVR
      301 LPHGNGETIR LARGASLSDF ADKIDANPAA LVQALFNLGE MVTATQSVGD ETLELLGSEM
      361 NYNVQVVSPE DEDRELLESF DLSYGEDEGG EEDLQVRPPV VTVMGHVDHG KTRLLDTIRK
      421 ANVREAEAGG ITQHIGAYQV AVDLDGSQRL ITFIDTPGHE AFTAMRARGA KATDIAILVV
      481 AADDGVMPQT VEAINHAQAA DVPIVVAVNK IDKEGADPAK IRGQLTEYGL VPEEFGGDTM
      541 FVDISAKQGT NIEALEEAVL LTADAALDLR ANPDMEAQGV AIEAHLDRGR GPVATVLVQR
      601 GTLRVGDSVV AGDAYGRVRR MVDEHGEDVE VALPSRPVQV IGFTSVPGAG DNFLVVDEDR
      661 IARQIADRRS ARKRNALAAR SRKRISLEDL DSALKETSQL NLILKGDNAG TVEALEEALM
      721 GIQVDDEVVL RVIDRGVGGI TETNVNLASA SDAVIIGFNV RAEGKATELA SREGVEIRYY
      781 SVIYQAIDEI EQALRGLLKP IYEENQLGRA EIRALFRSSK VGLIAGCLVT SGVMRRNAKA
      841 RLLRDNIVVA ENLSIASLRR EKDDVTEVRD GFECGLTLGY ADIKEGDVIE SYELVQKERA
//