LOCUS SIU01480.1 123 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE Sn-GLYCEROL-3-PHOSPHATE TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER UGPAA [FIRST PART] protein. ACCESSION LT708304-2894 PROTEIN_ID SIU01480.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="ugpAa" /locus_tag="BQ2027_MB2860C" /note="Mb2860c, ugpAa, len: 123 aa. Similar to 5' end of Rv2835c, len: 303 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 85 aa overlap). Probable ugpA, Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter (see citation below), similar to various permeases e.g. Q9RK71|SCF11.19 PROBABLE SUGAR TRANSPORTER INNER MEMBRANE PROTEIN from Streptomyces coelicolor (316 aa), FASTA scores: opt: 643, E(): 3.1e-35, (38.85% identity in 291 aa overlap); Q9KDY4|BH1077 GLYCEROL-3-PHOSPHATE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (315 aa), FASTA scores: opt: 548, E(): 6.2e-29, (31.5% identity in 295 aa overlap); AAK78407|CAC0427 GLYCEROL-3-PHOSPHATE ABC-TRANSPORTER, PERMEASE COMPONENT from Clostridium acetobutylicum (304 aa), FASTA scores: opt: 538, E(): 2.8e-28, (29.1% identity in 292 aa overlap); etc. Contains PS00062 Aldo/keto reductase family signature 2, and PS00402 Binding-protein-dependent transport systems inner membrane comp signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, ugpA exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) splits ugpA into 2 parts, ugpAa and ugpAb. Mb2860c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y2B6" /db_xref="InterPro:IPR035906" /db_xref="UniProtKB/TrEMBL:A0A1R3Y2B6" BEGIN 1 MAAPQRARLR SSKERVRDYA LFVVLVGPNV ALLLLFVYRP LADNIRLSFF DWNVSDPSAR 61 FVGLSNYTEW FTRSDTRQIV FNTAVSPVPR WSARWCWGWR WRCCSIDRCV DETWCAPLFS 121 RRS //