LOCUS       SIU01480.1               123 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            Sn-GLYCEROL-3-PHOSPHATE TRANSPORT INTEGRAL MEMBRANE PROTEIN
            ABC TRANSPORTER UGPAA [FIRST PART] protein.
ACCESSION   LT708304-2894
PROTEIN_ID  SIU01480.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ugpAa"
                     /locus_tag="BQ2027_MB2860C"
                     /note="Mb2860c, ugpAa, len: 123 aa. Similar to 5' end of
                     Rv2835c, len: 303 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (100.0% identity in 85 aa overlap). Probable
                     ugpA, Sn-glycerol-3-phosphate transport integral membrane
                     protein ABC transporter (see citation below), similar to
                     various permeases e.g. Q9RK71|SCF11.19 PROBABLE SUGAR
                     TRANSPORTER INNER MEMBRANE PROTEIN from Streptomyces
                     coelicolor (316 aa), FASTA scores: opt: 643, E(): 3.1e-35,
                     (38.85% identity in 291 aa overlap); Q9KDY4|BH1077
                     GLYCEROL-3-PHOSPHATE ABC TRANSPORTER (PERMEASE) from
                     Bacillus halodurans (315 aa), FASTA scores: opt: 548, E():
                     6.2e-29, (31.5% identity in 295 aa overlap);
                     AAK78407|CAC0427 GLYCEROL-3-PHOSPHATE ABC-TRANSPORTER,
                     PERMEASE COMPONENT from Clostridium acetobutylicum (304
                     aa), FASTA scores: opt: 538, E(): 2.8e-28, (29.1% identity
                     in 292 aa overlap); etc. Contains PS00062 Aldo/keto
                     reductase family signature 2, and PS00402
                     Binding-protein-dependent transport systems inner membrane
                     comp signature. REMARK-M.bovis-M.tuberculosis: In
                     Mycobacterium tuberculosis strain H37Rv, ugpA exists as a
                     single gene. In Mycobacterium bovis, a frameshift due to a
                     single base deletion (t-*) splits ugpA into 2 parts, ugpAa
                     and ugpAb. Mb2860c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y2B6"
                     /db_xref="InterPro:IPR035906"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y2B6"
BEGIN
        1 MAAPQRARLR SSKERVRDYA LFVVLVGPNV ALLLLFVYRP LADNIRLSFF DWNVSDPSAR
       61 FVGLSNYTEW FTRSDTRQIV FNTAVSPVPR WSARWCWGWR WRCCSIDRCV DETWCAPLFS
      121 RRS
//