LOCUS SIU01456.1 270 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Type II secretory pathway, component ExeA protein. ACCESSION LT708304-2870 PROTEIN_ID SIU01456.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2837" /note="Mb2837, -, len: 270 aa. Equivalent to Rv2813, len: 270 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 270 aa overlap). Conserved hypothetical protein, similar to various proteins (notably secreted proteins) e.g. Q9ZFL2 HYPOTHETICAL 30.4 KDA PROTEIN from Bacillus stearothermophilus (266 aa), FASTA scores: opt: 518, E(): 1.4e-26, (33.85% identity in 266 aa overlap); P45754|GSPA_AERHY|EXEA GENERAL SECRETION PATHWAY PROTEIN from Aeromonas hydrophila (547 aa), FASTA scores: opt: 386, E(): 1.1e-17, (32.05% identity in 265 aa overlap); Q9KPC7|VC2445 GENERAL SECRETION PATHWAY PROTEIN A from Vibrio cholerae (529 aa), FASTA scores: opt: 366, E(): 2.2e-16, (31.1% identity in 270 aa overlap); Q56674|VC0403 MANNOSE-SENSITIVE HEMAGGLUTININ D from Vibrio cholerae (281 aa), FASTA scores: opt: 317, E(): 2.1e-13, (27.85% identity in 262 aa overlap); etc. Also highly similar to AAK40072 Rv2813-LIKE PROTEIN from Mycobacterium celatum (270 aa), FASTA scores: opt: 1628, E(): 2.8e-99, (90.75% identity in 270 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop)." /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="UniProtKB/TrEMBL:A0A1R3Y331" BEGIN 1 MMHKLISYYG FSRMPFGRDL APGMLHRHSA HNEAVARIGW CIADRRIGVI TGEVGAGKTV 61 AVRAALASLD RSRHTVIYLP DPTVGVQGIH HRIVASLGGQ PLTHHATLAP QAADALAAEQ 121 AERGRTPVVV VEEAHLLGYD QLEALRLLTN HDLDSSSPFA CLLIGQPTLR RRMKLGVLAA 181 LDQRIGLRYA MPPMTDTNTG SYLRHHLKLA GRDDALFSDD AIGLIHQTSR GYPRAVNNLA 241 LQALVAAFAA DKAIVDESTT RTAIAEVTAD //