LOCUS       SIU01423.1               438 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ZINC PROTEASE PEPR protein.
ACCESSION   LT708304-2837
PROTEIN_ID  SIU01423.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pepR"
                     /locus_tag="BQ2027_MB2805C"
                     /note="Mb2805c, pepR, len: 438 aa. Equivalent to Rv2782c,
                     len: 438 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 438 aa overlap). Probable pepR,
                     protease/peptidase (EC 3.4.99.-), equivalent to
                     O32965|YR82_MYCLE|ML0855|MLCB22.26c HYPOTHETICAL ZINC
                     PROTEASE from Mycobacterium leprae (445 aa), FASTA scores:
                     opt: 2346, E(): 4.3e-146, (84.3% identity in 421 aa
                     overlap). Also highly similar to others e.g.
                     O86835|YA12_STRCO|SC9A10.02 from Streptomyces coelicolor
                     (459 aa), FASTA scores: opt: 1394, E(): 1.1e-83, (51.9%
                     identity in 416 aa overlap); Q04805|YMXG_BACSU|YMXG from
                     Bacillus subtilis (409 aa), FASTA scores: opt: 1014, E():
                     7.9e-59, (37.55% identity in 410 aa overlap);
                     Q9KA85|BH2405 from Bacillus halodurans (413 aa), FASTA
                     scores: opt: 967, E(): 9.6e-56, (38.6% identity in 417 aa
                     overlap); etc. Contains PS00143 Insulinase family,
                     zinc-binding region signature. BELONGS TO PEPTIDASE FAMILY
                     M16, ALSO KNOWN AS THE INSULINASE FAMILY. COFACTOR:
                     REQUIRES DIVALENT CATIONS FOR ACTIVITY. BINDS ZINC.
                     Protein product from Mb2805c detected using SWATH mass
                     spectrometry. Mb2805c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A5S9"
                     /db_xref="InterPro:IPR001431"
                     /db_xref="InterPro:IPR007863"
                     /db_xref="InterPro:IPR011249"
                     /db_xref="InterPro:IPR011765"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5S9"
BEGIN
        1 MPRRSPADPA AALAPRRTTL PGGLRVVTEF LPAVHSASVG VWVGVGSRDE GATVAGAAHF
       61 LEHLLFKSTP TRSAVDIAQA MDAVGGELNA FTAKEHTCYY AHVLGSDLPL AVDLVADVVL
      121 NGRCAADDVE VERDVVLEEI AMRDDDPEDA LADMFLAALF GDHPVGRPVI GSAQSVSVMT
      181 RAQLQSFHLR RYTPERMVVA AAGNVDHDGL VALVREHFGS RLVRGRRPVA PRKGTGRVNG
      241 SPRLTLVSRD AEQTHVSLGI RTPGRGWEHR WALSVLHTAL GGGLSSRLFQ EVRETRGLAY
      301 SVYSALDLFA DSGALSVYAA CLPERFADVM RVTADVLESV ARDGITEAEC GIAKGSLRGG
      361 LVLGLEDSSS RMSRLGRSEL NYGKHRSIEH TLRQIEQVTV EEVNAVARHL LSRRYGAAVL
      421 GPHGSKRSLP QQLRAMVG
//