LOCUS       SIU01413.1               245 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 DIHYDRODIPICOLINA
            TE REDUCTASE DAPB (DHPR) protein.
ACCESSION   LT708304-2827
PROTEIN_ID  SIU01413.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="dapB"
                     /locus_tag="BQ2027_MB2795C"
                     /note="Mb2795c, dapB, len: 245 aa. Equivalent to Rv2773c,
                     len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.2% identity in 245 aa overlap). dapB,
                     dihydrodipicolinate reductase (EC 1.3.1.26) (see first
                     citation below), highly similar to many e.g.
                     P40110|DAPB_CORGL from Corynebacterium glutamicum
                     (Brevibacterium flavum) (248 aa), FASTA scores: opt: 1030,
                     E(): 1.8e-58, (65.45% identity in 246 aa overlap);
                     O86836|DAPB_STRCO|SC9A10.03 from Streptomyces coelicolor
                     (250 aa), FASTA scores: opt: 997, E(): 2.3e-56, (61.15%
                     identity in 247 aa overlap); P42976|DAPB_BACSU from
                     Bacillus subtilis (267 aa), FASTA scores: opt: 608, E():
                     1.7e-31, (45.95% identity in 209 aa overlap);
                     P46829|DAPB_MYCBO from Mycobacterium bovis (see second
                     citation below) (271 aa), FASTA scores: opt: 505, E():
                     6.3e-25, (36.2% identity in 246 aa overlap); etc. BELONGS
                     TO THE DIHYDRODIPICOLINATE REDUCTASE FAMILY. Protein
                     product from Mb2795c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb2795c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:Q7TXX0"
                     /db_xref="InterPro:IPR000846"
                     /db_xref="InterPro:IPR022663"
                     /db_xref="InterPro:IPR022664"
                     /db_xref="InterPro:IPR023940"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TXX0"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MRVGVLGAKG KVGATMVRAV AAADDLTLSA ELDAGDPLSL LTDGNTEVVI DFTHPDVVMG
       61 NLEFLIDNGI HAVVGTTGFT AERFQQVESW LVAKPNTSVL IAPNFAIGAV LSMHFAKQAA
      121 RFFDSAEVIE LHHPHKAEAP SGTAARTAKL IAEARKGLPP NPDATSTSLP GARGADVDGI
      181 PVHAVRLAGL VAHQEVLFGT EGEILTIRHD SLDRTSFVPG VLLAVRRIAE RPGLTVGLEP
      241 LLDLH
//