LOCUS       SIU01398.1               131 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 possible
            toxin vapc42. contains pin domain. protein.
ACCESSION   LT708304-2812
PROTEIN_ID  SIU01398.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="vapc42"
                     /locus_tag="BQ2027_MB2780C"
                     /note="Mb2780c, -, len: 131 aa. Equivalent to Rv2759c,
                     len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 131 aa overlap). Conserved
                     hypothetical protein, highly similar to three M.
                     tuberculosis hypothetical proteins
                     O07769|Y609_MYCTU|Rv0609|MT0638|MTCY19H5.13c (133 aa),
                     FASTA scores: opt: 364, E(): 5.1e-18, (49.6% identity in
                     131 aa overlap); P96914|Y624_MYCTU|Rv0624|MT0652|MTCY20H10
                     .05 (131 aa), FASTA scores: opt: 324, E(): 2.9e-15,
                     (42.85% identity in 126 aa overlap); and
                     Q10874|YJ82_MYCTU|Rv1982c|MT2034|MTCY39.37 (139 aa), FASTA
                     scores: opt: 271, E(): 1.4e-11, (38.6% identity in 127 aa
                     overlap). Also similar to other hypothetical proteins from
                     other bacteria e.g. CAC45376|SMC00900 CONSERVED
                     HYPOTHETICAL PROTEIN from Rhizobium meliloti
                     (Sinorhizobium meliloti) (128 aa), FASTA scores: opt: 286,
                     E(): 1.2e-12, (39.55% identity in 129 aa overlap);
                     Q981I7|MLL9357 HYPOTHETICAL PROTEIN from Rhizobium loti
                     (Mesorhizobium loti) (131 aa), FASTA scores: opt: 257,
                     E(): 1.2e-10, (36.35% identity in 132 aa overlap);
                     Q9AAG1|CC0639 HYPOTHETICAL PROTEIN from Caulobacter
                     crescentus (131 aa), FASTA scores: opt: 217, E(): 6.9e-08,
                     (33.35% identity in 132 aa overlap); etc. Mb2780c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P67243"
                     /db_xref="InterPro:IPR002716"
                     /db_xref="InterPro:IPR022907"
                     /db_xref="InterPro:IPR029060"
                     /db_xref="UniProtKB/Swiss-Prot:P67243"
BEGIN
        1 MIVDTSAIVA IVSGESGAQV LKEALERSPN SRMSAPNYVE LCAIMQRRDR PEISRLVDRL
       61 LDDYGIQVEA VDADQARVAA QAYRDYGRGS GHPARLNLGD TYSYALAQVT GEPLLFRGDD
      121 FTHTDIRPAC T
//