LOCUS SIU01398.1 131 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 possible toxin vapc42. contains pin domain. protein. ACCESSION LT708304-2812 PROTEIN_ID SIU01398.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="vapc42" /locus_tag="BQ2027_MB2780C" /note="Mb2780c, -, len: 131 aa. Equivalent to Rv2759c, len: 131 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 131 aa overlap). Conserved hypothetical protein, highly similar to three M. tuberculosis hypothetical proteins O07769|Y609_MYCTU|Rv0609|MT0638|MTCY19H5.13c (133 aa), FASTA scores: opt: 364, E(): 5.1e-18, (49.6% identity in 131 aa overlap); P96914|Y624_MYCTU|Rv0624|MT0652|MTCY20H10 .05 (131 aa), FASTA scores: opt: 324, E(): 2.9e-15, (42.85% identity in 126 aa overlap); and Q10874|YJ82_MYCTU|Rv1982c|MT2034|MTCY39.37 (139 aa), FASTA scores: opt: 271, E(): 1.4e-11, (38.6% identity in 127 aa overlap). Also similar to other hypothetical proteins from other bacteria e.g. CAC45376|SMC00900 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (128 aa), FASTA scores: opt: 286, E(): 1.2e-12, (39.55% identity in 129 aa overlap); Q981I7|MLL9357 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (131 aa), FASTA scores: opt: 257, E(): 1.2e-10, (36.35% identity in 132 aa overlap); Q9AAG1|CC0639 HYPOTHETICAL PROTEIN from Caulobacter crescentus (131 aa), FASTA scores: opt: 217, E(): 6.9e-08, (33.35% identity in 132 aa overlap); etc. Mb2780c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:P67243" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR022907" /db_xref="InterPro:IPR029060" /db_xref="UniProtKB/Swiss-Prot:P67243" BEGIN 1 MIVDTSAIVA IVSGESGAQV LKEALERSPN SRMSAPNYVE LCAIMQRRDR PEISRLVDRL 61 LDDYGIQVEA VDADQARVAA QAYRDYGRGS GHPARLNLGD TYSYALAQVT GEPLLFRGDD 121 FTHTDIRPAC T //