LOCUS       SIU01393.1               250 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            thymidylate synthase thyx (ts) (tsase) protein.
ACCESSION   LT708304-2807
PROTEIN_ID  SIU01393.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="thyx"
                     /locus_tag="BQ2027_MB2775C"
                     /note="Mb2775c, -, len: 250 aa. Equivalent to Rv2754c,
                     len: 250 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 250 aa overlap). Conserved
                     hypothetical ala-rich protein, equivalent to
                     Q9CBW3|YF14_MYCLE|ML1514 HYPOTHETICAL 28.0 KDA PROTEIN
                     from Mycobacterium leprae (254 aa), FASTA scores: opt:
                     1351, E(): 1e-84, (81.5% identity in 254 aa overlap). Also
                     highly similar to 40111|YDAP_CORGL from Corynebacterium
                     glutamicum (Brevibacterium flavum) (250 aa), FASTA scores:
                     opt: 1071, E(): 1.2e-65, (62.85% identity in 245 aa
                     overlap); Q05259|VG48_BPML5 GENE 48 PROTEIN (GP48) from
                     Mycobacteriophage L5 (243 aa), FASTA scores: opt: 610,
                     E(): 3.2e-34, (49.55% identity in 220 aa overlap);
                     O64238|VG48_BPMD2 GENE 48 PROTEIN (GP48) from
                     Mycobacteriophage D29 (235 aa), FASTA scores: opt: 593,
                     E(): 4.5e-33, (46.95% identity in 245 aa overlap); etc.
                     BELONGS TO THE THY1 FAMILY. Protein product from Mb2775c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb2775c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P66931"
                     /db_xref="InterPro:IPR003669"
                     /db_xref="InterPro:IPR036098"
                     /db_xref="UniProtKB/Swiss-Prot:P66931"
BEGIN
        1 MAETAPLRVQ LIAKTDFLAP PDVPWTTDAD GGPALVEFAG RACYQSWSKP NPKTATNAGY
       61 LRHIIDVGHF SVLEHASVSF YITGISRSCT HELIRHRHFS YSQLSQRYVP EKDSRVVVPP
      121 GMEDDADLRH ILTEAADAAR ATYSELLAKL EAKFADQPNA ILRRKQARQA ARAVLPNATE
      181 TRIVVTGNYR AWRHFIAMRA SEHADVEIRR LAIECLRQLA AVAPAVFADF EVTTLADGTE
      241 VATSPLATEA
//