LOCUS       SIU01392.1               300 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            DIHYDRODIPICOLINATE SYNTHASE DAPA (DHDPS) (DIHYDRODIPICOLINATE
            SYNTHETASE) protein.
ACCESSION   LT708304-2806
PROTEIN_ID  SIU01392.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="dapA"
                     /locus_tag="BQ2027_MB2774C"
                     /note="Mb2774c, dapA, len: 300 aa. Equivalent to Rv2753c,
                     len: 300 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 300 aa overlap). Probable dapA,
                     dihydrodipicolinate synthase (EC 4.2.1.52), equivalent to
                     Q9CBW4|DAPA_MYCLE|ML1513 DIHYDRODIPICOLINATE SYNTHASE from
                     Mycobacterium leprae (300 aa), FASTA scores: opt: 1699,
                     E(): 2.2e-98, (86.65% identity in 300 aa overlap). Also
                     highly similar to many e.g. P19808|DAPA_CORGL from
                     Corynebacterium glutamicum (Brevibacterium flavum) (301
                     aa), FASTA scores: opt: 1089, E(): 2e-60, (58.7% identity
                     in 288 aa overlap); O86841|DAPA_STRCO|SC9A10.08 from
                     Streptomyces coelicolor (299 aa), FASTA scores: opt: 1044,
                     E(): 1.3e-57, (55.75% identity in 287 aa overlap);
                     P05640|DAPA_ECOLI (292 aa), FASTA scores: opt: 515, E():
                     0, (33.8% identity in 287 aa overlap); etc. Contains
                     PS00665 and PS00666 Dihydrodipicolinate synthetase
                     signatures 1 and 2. BELONGS TO THE DHDPS FAMILY. Protein
                     product from Mb2774c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb2774c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P63946"
                     /db_xref="InterPro:IPR002220"
                     /db_xref="InterPro:IPR005263"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="InterPro:IPR020624"
                     /db_xref="InterPro:IPR020625"
                     /db_xref="UniProtKB/Swiss-Prot:P63946"
BEGIN
        1 MTTVGFDVAA RLGTLLTAMV TPFSGDGSLD TATAARLANH LVDQGCDGLV VSGTTGESPT
       61 TTDGEKIELL RAVLEAVGDR ARVIAGAGTY DTAHSIRLAK ACAAEGAHGL LVVTPYYSKP
      121 PQRGLQAHFT AVADATELPM LLYDIPGRSA VPIEPDTIRA LASHPNIVGV KDAKADLHSG
      181 AQIMADTGLA YYSGDDALNL PWLAMGATGF ISVIAHLAAG QLRELLSAFG SGDIATARKI
      241 NIAVAPLCNA MSRLGGVTLS KAGLRLQGID VGDPRLPQVA ATPEQIDALA ADMRAASVLR
//