LOCUS SIU01390.1 296 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 O-Methyltransfera
se involved in polyketide biosynthesis protein.
ACCESSION LT708304-2804
PROTEIN_ID SIU01390.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/locus_tag="BQ2027_MB2772"
/note="Mb2772, -, len: 296 aa. Equivalent to Rv2751, len:
296 aa, from Mycobacterium tuberculosis strain H37Rv,
(100.0% identity in 296 aa overlap). Conserved
hypothetical protein, similar in part to others e.g.
Q98LR1|MLR0915 HYPOTHETICAL PROTEIN from Rhizobium loti
(Mesorhizobium loti) (299 aa), FASTA scores: opt: 279,
E(): 1.6e-11, (32.85% identity in 210 aa overlap);
Q9FBX1|SC8E7.10 CONSERVED HYPOTHETICAL PROTEIN from
Streptomyces coelicolor (283 aa), FASTA scores: opt: 232,
E(): 2.4e-08, (27.9% identity in 269 aa overlap); Q9FMY9
HYPOTHETICAL PROTEIN (GENOMIC DNA, CHROMOSOME 5, P1
CLONE:MJB21) from Arabidopsis thaliana (Mouse-ear cress)
(370 aa), FASTA scores: opt: 205, E(): 2.1e-06, (28.9%
identity in 211 aa overlap); etc. Also similar in part to
several proteins from Mycobacterium tuberculosis:
P72053|Rv3787c|MTCY13D12.21 HYPOTHETICAL 33.4 KDA PROTEIN
(308 aa), FASTA scores: opt: 266, E(): 1.3e-10, (29.6%
identity in 267 aa overlap);
O53795|MBE50c|Rv0731c|MTV041.05c HYPOTHETICAL 34.9 KDA
PROTEIN (318 aa), FASTA scores: opt: 266, E(): 1.3e-10,
(32.05% identity in 281 aa overlap);
O53841|Rv0830|MTV043.22 HYPOTHETICAL 33.4 KDA PROTEIN (301
aa), FASTA scores: opt: 263, E(): 2e-10, (31.3% identity
in 262 aa overlap); etc. BELONGS TO THE MTCY13D12.21 /
MTCY210.45C / MTCY78.29C FAMILY. Protein product from
Mb2772 detected using shotgun mass spectrometry and SWATH
mass spectrometry. Mb2772 found to be expressed during
exponential growth in Sauton's minimal media by
RNA-sequencing."
/db_xref="GOA:A0A1R3Y226"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR011610"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:A0A1R3Y226"
BEGIN
1 MARNPAAQTA FGPMVLAAVE QNEPPGRRLV DDDLADLFLP RPLRWLAGAT RSAVLRRLLI
61 SASEWSGRGL WANLACRKRF IGDKLDEALG DIDAVVILGA GLDTRAYRLT RRVRMPVFEV
121 DLPVNIARKA KTVRRVLGEL PLSVRLVALD FEHDDLLTAL AEHGYRTEYR VFFVCEGVTQ
181 YLTERAVRRT LEGLRAAAPG SRMVFTYVRR DFIDGTNRYG TRTLYHTVRQ RRQLWHFGLD
241 PEEVAGFLAD YGWRLTEQAG PEELVQRYVE PTGRNLNASQ IEWSAYAEKS EPVTPR
//