LOCUS       SIU01383.1               270 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 CONSERVED
            35 KDA ALANINE RICH PROTEIN protein.
ACCESSION   LT708304-2797
PROTEIN_ID  SIU01383.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="35kd_ag"
                     /locus_tag="BQ2027_MB2765C"
                     /note="Mb2765c, 35kd_ag, len: 270 aa. Equivalent to
                     Rv2744c, len: 270 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (99.6% identity in 270 aa overlap). 35kd_ag,
                     conserved ala-rich protein 35-kd antigen (see citation
                     below). N-terminal part is equivalent to
                     Q49840|MLCB33.06c|B2235_C2_187 HYPOTHETICAL PROTEIN from
                     Mycobacterium leprae (167 aa), FASTA scores: opt: 789,
                     E(): 3.4e-35, (85.05% identity in 147 aa overlap); and
                     C-terminal part equivalent to
                     Q49845|MLCB33.05c|B2235_C3_214 HYPOTHETICAL PROTEIN from
                     Mycobacterium leprae (114 aa), FASTA scores: opt: 465,
                     E(): 3.6e-18, (65.8% identity in 114 aa overlap); note
                     that these two proteins from Mycobacterium leprae are
                     adjacent. Shows some similarity with
                     Q55707||Y617_SYNY3|SLL0617 HYPOTHETICAL 28.9 KDA PROTEIN
                     from Synechocystis sp. strain PCC 6803 (267 aa), FASTA
                     scores: opt: 155, E(): 0.19, (23.4% identity in 252 aa
                     overlap); and C-terminus of Q9L4N1|EMM M PROTEIN from
                     Streptococcus equisimilis (592 aa), FASTA scores: opt:
                     165, E(): 0.11, (23.45% identity in 260 aa overlap).
                     C-terminus also similar to AAK45945|MT1676 CONSERVED
                     HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis
                     strain CDC1551 (85 aa), FASTA scores: opt: 159, E():
                     0.047, (50.9% identity in 55 aa overlap). Protein product
                     from Mb2765c detected using shotgun mass spectrometry.
                     Mb2765c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="InterPro:IPR007157"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y211"
BEGIN
        1 MANPFVKAWK YLMALFSSKI DEHADPKVQI QQAIEEAQRT HQALTQQAAQ VIGNQRQLEM
       61 RLNRQLADIE KLQVNVRQAL TLADQATAAG DAAKATEYNN AAEAFAAQLV TAEQSVEDLK
      121 TLHDQALSAA AQAKKAVERN AMVLQQKIAE RTQLLSQLEQ AKMQEQVSAS LRSMSELAAP
      181 GNTPSLDEVR DKIERRYANA IGSAELAESS VQGRMLEVEQ AGIQMAGHSR LEQIRASMRG
      241 EALPAGGTTA TPRPATETSG GAIAEQPYGQ
//