LOCUS       SIU01366.1               301 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            conserved integral membrane alanine valine and leucine
            rich protein protein.
ACCESSION   LT708304-2780
PROTEIN_ID  SIU01366.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2748C"
                     /note="Mb2748c, -, len: 301 aa. Equivalent to Rv2729c,
                     len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.0% identity in 301 aa overlap). Probable conserved
                     integral membrane ala-, val-, leu-rich protein, similar to
                     P42459|YLEU_CORGL HYPOTHETICAL 29.6 KDA PROTEIN from
                     Corynebacterium glutamicum (Brevibacterium flavum)(270
                     aa), FASTA scores: opt: 365, E(): 4.7e-15, (30.75%
                     identity in 221 aa overlap); and to other integral
                     membrane proteins (principally from Streptomyces sp.) e.g.
                     Q9EWZ8|2SCG38.21 from Streptomyces coelicolor (302 aa),
                     FASTA scores: opt: 365, E(): 5.2e-15, (32.0% identity in
                     278 aa overlap); Q9S267|SCI30A.06 from Streptomyces
                     coelicolor (297 aa), FASTA scores: opt: 356, E(): 1.8e-14,
                     (31.5% identity in 289 aa overlap); AAK81278|CAC3346 from
                     Clostridium acetobutylicum (472 aa), FASTA scores: opt:
                     154, E(): 0.038, (24.1% identity in 224 aa overlap); etc.
                     Mb2748c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y2U4"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y2U4"
BEGIN
        1 MASVEFATIL ALGAALLAGI GYVTLQRSAR QVTAEEYVGH LTLFHLSLRH ALWWLGSLAA
       61 VASFTLQAIA LTMGSVVLVQ SLQATALLFA LLIDARLTHH RCTPREWMWA VLLAGAVAVI
      121 VMSGNPAAGT TRAPFSTWAV VAVVVVPAVV LCVVGARIAS GSLSAVLLAV ASSATLAVFT
      181 VLTKGVVTEL GEGFATLIRT PELYAWILVL PIGLMLQQSS LRVGALTASL PTITVARPVI
      241 ASVLGITVLD EVLHTGRVAL VALVAVVVVV VVATVALARD EVAMMTVSAG ELGAAGQLAV
      301 R
//