LOCUS SIU01366.1 301 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable conserved integral membrane alanine valine and leucine rich protein protein. ACCESSION LT708304-2780 PROTEIN_ID SIU01366.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2748C" /note="Mb2748c, -, len: 301 aa. Equivalent to Rv2729c, len: 301 aa, from Mycobacterium tuberculosis strain H37Rv, (99.0% identity in 301 aa overlap). Probable conserved integral membrane ala-, val-, leu-rich protein, similar to P42459|YLEU_CORGL HYPOTHETICAL 29.6 KDA PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum)(270 aa), FASTA scores: opt: 365, E(): 4.7e-15, (30.75% identity in 221 aa overlap); and to other integral membrane proteins (principally from Streptomyces sp.) e.g. Q9EWZ8|2SCG38.21 from Streptomyces coelicolor (302 aa), FASTA scores: opt: 365, E(): 5.2e-15, (32.0% identity in 278 aa overlap); Q9S267|SCI30A.06 from Streptomyces coelicolor (297 aa), FASTA scores: opt: 356, E(): 1.8e-14, (31.5% identity in 289 aa overlap); AAK81278|CAC3346 from Clostridium acetobutylicum (472 aa), FASTA scores: opt: 154, E(): 0.038, (24.1% identity in 224 aa overlap); etc. Mb2748c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3Y2U4" /db_xref="UniProtKB/TrEMBL:A0A1R3Y2U4" BEGIN 1 MASVEFATIL ALGAALLAGI GYVTLQRSAR QVTAEEYVGH LTLFHLSLRH ALWWLGSLAA 61 VASFTLQAIA LTMGSVVLVQ SLQATALLFA LLIDARLTHH RCTPREWMWA VLLAGAVAVI 121 VMSGNPAAGT TRAPFSTWAV VAVVVVPAVV LCVVGARIAS GSLSAVLLAV ASSATLAVFT 181 VLTKGVVTEL GEGFATLIRT PELYAWILVL PIGLMLQQSS LRVGALTASL PTITVARPVI 241 ASVLGITVLD EVLHTGRVAL VALVAVVVVV VVATVALARD EVAMMTVSAG ELGAAGQLAV 301 R //