LOCUS SIU01357.1 217 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 REPRESSOR LEXA protein. ACCESSION LT708304-2771 PROTEIN_ID SIU01357.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="lexA" /locus_tag="BQ2027_MB2739" /note="Mb2739, lexA, len: 217 aa. Equivalent to Rv2720, len: 217 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 217 aa overlap). LexA repressor (EC 3.4.21.88) (see citations below), equivalent to Q49848|LEXA_MYCLE|ML1003|B2235_F2_55 LEXA REPRESSOR from Mycobacterium leprae (217 aa), FASTA scores: opt: 1255, E(): 7.1e-70, (89.8% identity in 216 aa overlap). Also highly similar to others e.g. O69979|LEXA_STRCO|SC4H2.24c from Streptomyces coelicolor (234 aa), FASTA scores: opt: 1034, E(): 2.6e-56, (70.5% identity in 217 aa overlap); O86847|LEXA_STRCL from Streptomyces clavuligerus (239 aa), FASTA scores: opt: 1021, E(): 1.6e-55, (69.1% identity in 217 aa overlap); Q9KAD3|LEXA_BACHD from Bacillus halodurans (207 aa), FASTA scores: opt: 645, E(): 1.5e-32, (47.9% identity in 213 aa overlap); etc. BELONGS TO PEPTIDASE FAMILY S24; ALSO KNOWN AS THE UMUD/LEXA FAMILY. Protein product from Mb2739 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2739 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:Q7TY15" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR039418" /db_xref="UniProtKB/Swiss-Prot:Q7TY15" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MLSADSALTE RQRTILDVIR ASVTSRGYPP SIREIGDAVG LTSTSSVAHQ LRTLERKGYL 61 RRDPNRPRAV NVRGADDAAL PPVTEVAGSD ALPEPTFAPV LGRIAAGGPI LAEEAVEDVF 121 PLPRELVGEG TLFLLKVIGD SMVEAAICDG DWVVVRQQNV ADNGDIVAAM IDGEATVKTF 181 KRAGGQVWLM PHNPAFDPIP GNDATVLGKV VTVIRKV //