LOCUS       SIU01357.1               217 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 REPRESSOR
            LEXA protein.
ACCESSION   LT708304-2771
PROTEIN_ID  SIU01357.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="lexA"
                     /locus_tag="BQ2027_MB2739"
                     /note="Mb2739, lexA, len: 217 aa. Equivalent to Rv2720,
                     len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.5% identity in 217 aa overlap). LexA repressor (EC
                     3.4.21.88) (see citations below), equivalent to
                     Q49848|LEXA_MYCLE|ML1003|B2235_F2_55 LEXA REPRESSOR from
                     Mycobacterium leprae (217 aa), FASTA scores: opt: 1255,
                     E(): 7.1e-70, (89.8% identity in 216 aa overlap). Also
                     highly similar to others e.g. O69979|LEXA_STRCO|SC4H2.24c
                     from Streptomyces coelicolor (234 aa), FASTA scores: opt:
                     1034, E(): 2.6e-56, (70.5% identity in 217 aa overlap);
                     O86847|LEXA_STRCL from Streptomyces clavuligerus (239 aa),
                     FASTA scores: opt: 1021, E(): 1.6e-55, (69.1% identity in
                     217 aa overlap); Q9KAD3|LEXA_BACHD from Bacillus
                     halodurans (207 aa), FASTA scores: opt: 645, E(): 1.5e-32,
                     (47.9% identity in 213 aa overlap); etc. BELONGS TO
                     PEPTIDASE FAMILY S24; ALSO KNOWN AS THE UMUD/LEXA FAMILY.
                     Protein product from Mb2739 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb2739 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:Q7TY15"
                     /db_xref="InterPro:IPR006197"
                     /db_xref="InterPro:IPR006199"
                     /db_xref="InterPro:IPR006200"
                     /db_xref="InterPro:IPR015927"
                     /db_xref="InterPro:IPR036286"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR036390"
                     /db_xref="InterPro:IPR039418"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TY15"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MLSADSALTE RQRTILDVIR ASVTSRGYPP SIREIGDAVG LTSTSSVAHQ LRTLERKGYL
       61 RRDPNRPRAV NVRGADDAAL PPVTEVAGSD ALPEPTFAPV LGRIAAGGPI LAEEAVEDVF
      121 PLPRELVGEG TLFLLKVIGD SMVEAAICDG DWVVVRQQNV ADNGDIVAAM IDGEATVKTF
      181 KRAGGQVWLM PHNPAFDPIP GNDATVLGKV VTVIRKV
//