LOCUS       SIU01334.1               154 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            deoxyuridine 5'-triphosphate nucleotidohydrolase dut (
            dutpase) (dutp pyrophosphatase) (deoxyuridine 5'-triphosphatase)
            (dutp diphosphatase) (deoxyuridine-triphosphatase) protein.
ACCESSION   LT708304-2748
PROTEIN_ID  SIU01334.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="dut"
                     /locus_tag="BQ2027_MB2716C"
                     /note="Mb2716c, dut, len: 154 aa. Equivalent to Rv2697c,
                     len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 154 aa overlap). Probable dut,
                     deoxyuridine 5'-triphosphate nucleotidohydrolase (EC
                     3.6.1.23), equivalent to Q49992|DUT_MYCLE|ML1028
                     DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE from
                     Mycobacterium leprae (154 aa), FASTA scores: opt: 928,
                     E(): 2.1e-51, (90.25% identity in 154 aa overlap). Also
                     highly similar to others e.g. O54134|DUT_STRCO|SC2E9.09
                     from Streptomyces coelicolor (183 aa), FASTA scores: opt:
                     534, E(): 1.2e-26, (56.1% identity in 148 aa overlap);
                     O66592|DUT_AQUAE|AQ_220 from Aquifex aeolicus (150 aa),
                     FASTA scores: opt: 398, E(): 3.3e-18, (48.05% identity in
                     152 aa overlap); Q9X3X5|DUT_ZYMMO from Zymomonas mobilis
                     (146 aa), FASTA scores: opt: 396, E(): 4.4e-18, (49.0%
                     identity in 147 aa overlap); etc. BELONGS TO THE DUTPASE
                     FAMILY. Protein product from Mb2716c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb2716c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:P0A553"
                     /db_xref="InterPro:IPR008181"
                     /db_xref="InterPro:IPR029054"
                     /db_xref="InterPro:IPR033704"
                     /db_xref="InterPro:IPR036157"
                     /db_xref="UniProtKB/Swiss-Prot:P0A553"
BEGIN
        1 MSTTLAIVRL DPGLPLPSRA HDGDAGVDLY SAEDVELAPG RRALVRTGVA VAVPFGMVGL
       61 VHPRSGLATR VGLSIVNSPG TIDAGYRGEI KVALINLDPA APIVVHRGDR IAQLLVQRVE
      121 LVELVEVSSF DEAGLASTSR GDGGHGSSGG HASL
//