LOCUS SIU01329.1 220 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 TRK SYSTEM POTASSIUM UPTAKE PROTEIN CEOC protein. ACCESSION LT708304-2743 PROTEIN_ID SIU01329.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="ceoC" /locus_tag="BQ2027_MB2711" /note="Mb2711, ceoC, len: 220 aa. Equivalent to Rv2692, len: 220 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 220 aa overlap). ceoC (alternate gene names: trkA and trkB), TRK system potassium uptake protein (see citation below), highly similar to others e.g. O54141|SC2E9.16c from Streptomyces coelicolor (226 aa), FASTA scores: opt: 870, E(): 9.4e-48, (58.8% identity in 216 aa overlap); Q58505|TRKA_METJA|MJ1105 from Methanococcus jannaschii (218 aa), FASTA scores: opt: 361, E(): 9.7e-16, (29.8% identity in 218 aa overlap); O27333|TRKA_METTH|MTH1265 from Methanobacterium thermoautotrophicum (216 aa), FASTA scores: opt: 326, E(): 1.5e-13, (30.1% identity in 216 aa overlap); etc. Also similar to downstream orf O07193|CEOB|TRKA|Rv2691|MTCY05A6.12 TRK SYSTEM POTASSIUM UPTAKE PROTEIN from Mycobacterium tuberculosis (227 aa), FASTA scores: opt: 259, E(): 2.6e-09, (26.55% identity in 226 aa overlap). Contains a motif common to NAD+ binding pockets (see citation below). BELONGS TO THE TRKA FAMILY. Protein product from Mb2711 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2711 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3Y1X0" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006036" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="UniProtKB/TrEMBL:A0A1R3Y1X0" BEGIN 1 MKVAVAGAGA VGRSVTRELV ENGHDITLIE RNPDHLDAAA IPEAHWRLGD ACELSLLESI 61 HLEEFDVVVA ATGDDKVNVV LSLLAKTEFA VPRVVARVND PRNEWLFNDA WGVDVAVSTP 121 RMLASLIEEA VTVGDLVRLM EFRTGQANLV EITLPDNTPW GGKPVRKLQL PRDAALVTIL 181 RGPRVIVPEA DEPLEGGDEL LFVAVTEAEE ELSRLLLPSM //