LOCUS       SIU01329.1               220 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 TRK
            SYSTEM POTASSIUM UPTAKE PROTEIN CEOC protein.
ACCESSION   LT708304-2743
PROTEIN_ID  SIU01329.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ceoC"
                     /locus_tag="BQ2027_MB2711"
                     /note="Mb2711, ceoC, len: 220 aa. Equivalent to Rv2692,
                     len: 220 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.5% identity in 220 aa overlap). ceoC (alternate gene
                     names: trkA and trkB), TRK system potassium uptake protein
                     (see citation below), highly similar to others e.g.
                     O54141|SC2E9.16c from Streptomyces coelicolor (226 aa),
                     FASTA scores: opt: 870, E(): 9.4e-48, (58.8% identity in
                     216 aa overlap); Q58505|TRKA_METJA|MJ1105 from
                     Methanococcus jannaschii (218 aa), FASTA scores: opt: 361,
                     E(): 9.7e-16, (29.8% identity in 218 aa overlap);
                     O27333|TRKA_METTH|MTH1265 from Methanobacterium
                     thermoautotrophicum (216 aa), FASTA scores: opt: 326, E():
                     1.5e-13, (30.1% identity in 216 aa overlap); etc. Also
                     similar to downstream orf
                     O07193|CEOB|TRKA|Rv2691|MTCY05A6.12 TRK SYSTEM POTASSIUM
                     UPTAKE PROTEIN from Mycobacterium tuberculosis (227 aa),
                     FASTA scores: opt: 259, E(): 2.6e-09, (26.55% identity in
                     226 aa overlap). Contains a motif common to NAD+ binding
                     pockets (see citation below). BELONGS TO THE TRKA FAMILY.
                     Protein product from Mb2711 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb2711 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y1X0"
                     /db_xref="InterPro:IPR003148"
                     /db_xref="InterPro:IPR006036"
                     /db_xref="InterPro:IPR006037"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="InterPro:IPR036721"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1X0"
BEGIN
        1 MKVAVAGAGA VGRSVTRELV ENGHDITLIE RNPDHLDAAA IPEAHWRLGD ACELSLLESI
       61 HLEEFDVVVA ATGDDKVNVV LSLLAKTEFA VPRVVARVND PRNEWLFNDA WGVDVAVSTP
      121 RMLASLIEEA VTVGDLVRLM EFRTGQANLV EITLPDNTPW GGKPVRKLQL PRDAALVTIL
      181 RGPRVIVPEA DEPLEGGDEL LFVAVTEAEE ELSRLLLPSM
//