LOCUS       SIU01328.1               227 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 TRK
            SYSTEM POTASSIUM UPTAKE PROTEIN CEOB protein.
ACCESSION   LT708304-2742
PROTEIN_ID  SIU01328.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ceoB"
                     /locus_tag="BQ2027_MB2710"
                     /note="Mb2710, ceoB, len: 227 aa. Equivalent to Rv2691,
                     len: 227 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 227 aa overlap). ceoB (alternate gene
                     name: trkA), TRK system potassium uptake protein (see
                     citation below), highly similar to others e.g.
                     Q53949|TRKA_STRCO|SC2E9.17c from Streptomyces coelicolor
                     (223 aa), FASTA scores: opt: 781, E(): 5.8e-42, (53.2%
                     identity in 220 aa overlap); O27333|TRKA_METTH|MTH1265
                     from Methanobacterium thermoautotrophicum (216 aa), FASTA
                     scores: opt: 287, E(): 5.3e-11, (27.0% identity in 211 aa
                     overlap); O54141|SC2E9.16c from Streptomyces coelicolor
                     (226 aa), FASTA scores: opt: 269, E(): 7.3e-10, (29.9%
                     identity in 214 aa overlap); etc. Also similar to upstream
                     orf O07194|CEOC|TRKA_MYCTU|TRKA|TRKB|Rv2692|MT2766|MTCY05A
                     6.13 TRK SYSTEM POTASSIUM UPTAKE PROTEIN from
                     Mycobacterium tuberculosis (220 aa), FASTA scores: opt:
                     259, E(): 3e-09, (26.55% identity in 226 aa overlap).
                     Contains a motif common to NAD+ binding pockets (see
                     citation below). BELONGS TO THE TRKA FAMILY. Protein
                     product from Mb2710 detected using shotgun mass
                     spectrometry. Mb2710 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y2B8"
                     /db_xref="InterPro:IPR003148"
                     /db_xref="InterPro:IPR006036"
                     /db_xref="InterPro:IPR006037"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="InterPro:IPR036721"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y2B8"
BEGIN
        1 MRVVVMGCGR VGASVADGLS RIGHEVAIID RDSAAFNRLS PQFAGERVLG QGFDRDVLLR
       61 AGIQGADAFA AVSSGDNSNI ISARLARETF GVPRVVARIY DAKRAEVYER LGIPTIATVP
      121 WTTDRLLNAL MQDTETAKWR DPTGTVAVAE VVLHEDWVGH RATDLEQATG ARIAFLIRFG
      181 TGVLPEPKTV LQAGDKVYIA AISGRAAEAA AIAALPPSED FESGARR
//