LOCUS SIU01328.1 227 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 TRK SYSTEM POTASSIUM UPTAKE PROTEIN CEOB protein. ACCESSION LT708304-2742 PROTEIN_ID SIU01328.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="ceoB" /locus_tag="BQ2027_MB2710" /note="Mb2710, ceoB, len: 227 aa. Equivalent to Rv2691, len: 227 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 227 aa overlap). ceoB (alternate gene name: trkA), TRK system potassium uptake protein (see citation below), highly similar to others e.g. Q53949|TRKA_STRCO|SC2E9.17c from Streptomyces coelicolor (223 aa), FASTA scores: opt: 781, E(): 5.8e-42, (53.2% identity in 220 aa overlap); O27333|TRKA_METTH|MTH1265 from Methanobacterium thermoautotrophicum (216 aa), FASTA scores: opt: 287, E(): 5.3e-11, (27.0% identity in 211 aa overlap); O54141|SC2E9.16c from Streptomyces coelicolor (226 aa), FASTA scores: opt: 269, E(): 7.3e-10, (29.9% identity in 214 aa overlap); etc. Also similar to upstream orf O07194|CEOC|TRKA_MYCTU|TRKA|TRKB|Rv2692|MT2766|MTCY05A 6.13 TRK SYSTEM POTASSIUM UPTAKE PROTEIN from Mycobacterium tuberculosis (220 aa), FASTA scores: opt: 259, E(): 3e-09, (26.55% identity in 226 aa overlap). Contains a motif common to NAD+ binding pockets (see citation below). BELONGS TO THE TRKA FAMILY. Protein product from Mb2710 detected using shotgun mass spectrometry. Mb2710 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y2B8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006036" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="UniProtKB/TrEMBL:A0A1R3Y2B8" BEGIN 1 MRVVVMGCGR VGASVADGLS RIGHEVAIID RDSAAFNRLS PQFAGERVLG QGFDRDVLLR 61 AGIQGADAFA AVSSGDNSNI ISARLARETF GVPRVVARIY DAKRAEVYER LGIPTIATVP 121 WTTDRLLNAL MQDTETAKWR DPTGTVAVAE VVLHEDWVGH RATDLEQATG ARIAFLIRFG 181 TGVLPEPKTV LQAGDKVYIA AISGRAAEAA AIAALPPSED FESGARR //