LOCUS       SIU01326.1               405 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 conserved
            alanine and valine and glycine rich protein protein.
ACCESSION   LT708304-2740
PROTEIN_ID  SIU01326.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2708C"
                     /note="Mb2708c, -, len: 405 aa. Equivalent to Rv2689c,
                     len: 405 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 405 aa overlap). Conserved
                     hypothetical ala-, val-, gly-rich protein, similar to
                     O54099|SC10A5.06 HYPOTHETICAL 49.5 KDA PROTEIN from
                     Streptomyces coelicolor (458 aa), FASTA scores: opt: 455,
                     E(): 2.7e-20, (38.35% identity in 417 aa overlap); and
                     shows weak similarity in part with several
                     methyltransferases (EC 2.1.1.-) e.g. Q9X0H9|TM1094
                     PUTATIVE RNA METHYLTRANSFERASE from Thermotoga maritima
                     (439 aa), FASTA scores: opt: 306, E(): 3e-11, (25.9%
                     identity in 436 aa overlap); AK79403|CAC1435
                     S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES from
                     Clostridium acetobutylicum (456 aa), FASTA scores: opt:
                     294, E(): 1.6e-10, (23.4% identity in 449 aa overlap);
                     Q9A8M7|CC1326 RNA METHYLTRANSFERASE from Caulobacter
                     crescentus (415 aa), FASTA scores: opt: 247, E(): 1.1e-07,
                     (28.4% identity in 433 aa overlap); etc. Equivalent to
                     AAK47078 from Mycobacterium tuberculosis strain CDC1551
                     (434 aa) but shorter 29 aa. Other less probable starts
                     possible. Protein product from Mb2708c detected using
                     SWATH mass spectrometry. Mb2708c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y2Q7"
                     /db_xref="InterPro:IPR002792"
                     /db_xref="InterPro:IPR010280"
                     /db_xref="InterPro:IPR012340"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y2Q7"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTRAGDDAVN LTLVTGAPAN GGSCVAHHEG RVVFVRYALP GERVRARVTA QRGSYWHAEA
       61 FEVIDPSPDR IGSLCSIAGA DGAGCCDLAF AAPEAARTLK AQVVANQLER LGRHSWQGEA
      121 QPLSDAGPTG WRIRVRLDVG ADRRPGFHRY HSGELVTDLD CGQLPVGMLD GLVAADWPPE
      181 AQLYVALDDD GERHVVCSVR QGPRNRTRTV TNVVEGAYHA HQRVHRRSWR VPVTAFWQAH
      241 RDAAAVYSDL IADWAQPAPG MTAWDLYGGA GVFAAVLGEA VGESGRVLTV DTSRLASGAA
      301 RAALVDLPQV EVVTGSVRRV LAVQPAGADL AVLDPPRSGA GREVVDLLAG AGVPRLIHIG
      361 CEAASFARDI GLYRGHGYAV EKIKVFDAFP LTHYVECVAL LTRKV
//