LOCUS SIU01322.1 428 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE ARSENIC-TRANSPORT INTEGRAL MEMBRANE PROTEIN ARSB1 protein. ACCESSION LT708304-2736 PROTEIN_ID SIU01322.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="arsB1" /locus_tag="BQ2027_MB2704" /note="Mb2704, arsB1, len: 428 aa. Equivalent to Rv2685, len: 428 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 428 aa overlap). Probable arsB1, arsenic-transport integral membrane protein, equivalent to P46838|AG45_MYCLE|ML1036 46 KDA PROBABLE INTEGRAL MEMBRANE PROTEIN (antigen 45, a transmembrane protein related to arsenical pumps) from Mycobacterium leprae (429 aa), FASTA scores: opt: 2048, E(): 7.3e-120, (74.25% identity in 427 aa overlap); and downstream ORF O07186|YQ84_MYCTU|ARSA|Rv2684|MT2758|MTCY05A6.05 PROBABLE INTEGRAL MEMBRANE PROTEIN ARSA from Mycobacterium tuberculosis (429 aa), FASTA scores: opt: 2154, E(): 1.9e-126, (76.8% identity in 427 aa overlap). Also highly similar to other proteins e.g. O59575|PH1912 HYPOTHETICAL 46.0 KDA PROTEIN from Pyrococcus horikoshii (424 aa), FASTA scores: opt: 1075, E(): 1.9e-59, (43.55% identity in 427 aa overlap); Q9UY19|PAB1107 TRANSPORT PROTEIN from Pyrococcus abyssi (425 aa), FASTA scores: opt: 1062, E(): 1.3e-58, (41.8% identity in 428 aa overlap); Q9KDI2|BH1231 HYPOTHETICAL 46.0 KDA PROTEIN from Bacillus halodurans (428 aa), FASTA scores: opt: 993, E(): 2.4e-54, (39.55% identity in 430 aa overlap); etc. BELONGS TO THE NADC/P/PHO87 FAMILY OF TRANSPORTERS, P SUBFAMILY. Note that previously known as arsB. Protein product from Mb2704 detected using SWATH mass spectrometry. Mb2704 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y1W7" /db_xref="InterPro:IPR000802" /db_xref="InterPro:IPR004680" /db_xref="UniProtKB/TrEMBL:A0A1R3Y1W7" BEGIN 1 MSIIAITVFV AGYALIASDR VSKTRVALTC AAIMVGAGIV GSDDVFYSHE AGIDWDVIFL 61 LLGMMIIVSV LRHTGVFEYV AIWAVKRANA APLRIMILLV LVTALGSALL DNVTTVLLIA 121 PVTLLVCDRL GVNSTPFLVA EVFASNVGGA ATLVGDPPNI IIASRAGLTF NDFLIHMAPA 181 VLVVMIALIG LLPWLLGSVT AEPDRVADVL SLNEREAIHD RGLLIKCGVV LVLVFAAFIA 241 HPVLHIQPSL VALLGAGVLV RFSGLERSDY LSSVEWDTLL FFAGLFVMVG ALVKTGVVEQ 301 LARAATELTG GNELLTVGLI LGISAPVSGI IDNIPYVATM TPIVTELVAA MPGHVHPDTF 361 WWALALSADF GGNLTAVGAS ANVVMLGIAR RSCTPISFWK FTRKGAVVTA VSLVLSAVYL 421 WLRYFVFG //