LOCUS SIU01307.1 369 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 AFG1 family ATPase protein. ACCESSION LT708304-2721 PROTEIN_ID SIU01307.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2689C" /note="Mb2689c, -, len: 369 aa. Equivalent to Rv2670c, len: 369 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 369 aa overlap). Conserved hypothetical protein, equivalent, but longer 164 aa, to O05683|MLC1351.22c HYPOTHETICAL 17.3 KDA PROTEIN from Mycobacterium leprae (160 aa), FASTA scores: opt: 847, E(): 1.2e-45, (82.4% identity in 159 aa overlap). And highly similar to Q9X824|SC9B1.04c PUTATIVE ATP/GTP-BINDING INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (350 aa), FASTA scores: opt: 1169, E(): 2e-65, (56.85% identity in 343 aa overlap); and Q9RWB0|DR0759 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (351 aa), FASTA scores: opt: 859, E(): 4e-46, (45.9% identity in 331 aa overlap). Also some similarity with other proteins e.g. P46442|YHCM_ECOLI|AAG58360|BAB37528 HYPOTHETICAL PROTEIN from Escherichia coli strains K12 and O157:H7 (375 aa), FASTA scores: opt: 237, E(): 2.1e-07, (28.0% identity in 325 aa overlap); Q9JRK2|NMA1520|NMB1306 PUTATIVE NUCLEOTIDE-BINDING PROTEIN from Neisseria meningitidis (serogroup A and B) (383 aa), FASTA scores: opt: 221, E(): 2.1e-06, (27.8% identity in 356 aa overlap); Q9HVX7|PA4438 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (364 aa), FASTA scores: opt: 211, E(): 8.5e-06, (28.9% identity in 353 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Protein product from Mb2689c detected using SWATH mass spectrometry." /db_xref="GOA:A0A1R3Y224" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR005654" /db_xref="InterPro:IPR027417" /db_xref="UniProtKB/TrEMBL:A0A1R3Y224" BEGIN 1 MTLIAARRYS ATMHGSASEA CGSVDHLVDR HPTVSPVRLI AQLRPPPTFA EVSFATYRPD 61 PVEPTQAAAV VACQDFCRQA VERRAGRKKW FGKRDVLPGV GLYLDGGFGV GKTHLLASAY 121 YQLPGTGPDA PTCPKAFATF GELTQLAGVF GFADCIDLLA NYTALCIDEF ELDDPGNTTL 181 ISRLLSALVE RGVSVAATSN TLPEQLGEGR FAAQDFLREI NTLASIFTTV RIEGPDYRHR 241 DLPPAPAPLS DEEVAARAAR VEGATLDDFD ALCAHLATMH PSRYLTLIEG VTAVFLTGVH 301 GIDDQNVALR LVALVDRLYD AGIPVVASGA KLDTIFSEEM LAGGYRKKYL RATSRLLALT 361 AGVIQAREP //