LOCUS       SIU01307.1               369 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 AFG1
            family ATPase protein.
ACCESSION   LT708304-2721
PROTEIN_ID  SIU01307.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2689C"
                     /note="Mb2689c, -, len: 369 aa. Equivalent to Rv2670c,
                     len: 369 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 369 aa overlap). Conserved
                     hypothetical protein, equivalent, but longer 164 aa, to
                     O05683|MLC1351.22c HYPOTHETICAL 17.3 KDA PROTEIN from
                     Mycobacterium leprae (160 aa), FASTA scores: opt: 847,
                     E(): 1.2e-45, (82.4% identity in 159 aa overlap). And
                     highly similar to Q9X824|SC9B1.04c PUTATIVE
                     ATP/GTP-BINDING INTEGRAL MEMBRANE PROTEIN from
                     Streptomyces coelicolor (350 aa), FASTA scores: opt: 1169,
                     E(): 2e-65, (56.85% identity in 343 aa overlap); and
                     Q9RWB0|DR0759 CONSERVED HYPOTHETICAL PROTEIN from
                     Deinococcus radiodurans (351 aa), FASTA scores: opt: 859,
                     E(): 4e-46, (45.9% identity in 331 aa overlap). Also some
                     similarity with other proteins e.g.
                     P46442|YHCM_ECOLI|AAG58360|BAB37528 HYPOTHETICAL PROTEIN
                     from Escherichia coli strains K12 and O157:H7 (375 aa),
                     FASTA scores: opt: 237, E(): 2.1e-07, (28.0% identity in
                     325 aa overlap); Q9JRK2|NMA1520|NMB1306 PUTATIVE
                     NUCLEOTIDE-BINDING PROTEIN from Neisseria meningitidis
                     (serogroup A and B) (383 aa), FASTA scores: opt: 221, E():
                     2.1e-06, (27.8% identity in 356 aa overlap); Q9HVX7|PA4438
                     HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (364 aa),
                     FASTA scores: opt: 211, E(): 8.5e-06, (28.9% identity in
                     353 aa overlap); etc. Contains PS00017 ATP/GTP-binding
                     site motif A (P-loop). Protein product from Mb2689c
                     detected using SWATH mass spectrometry."
                     /db_xref="GOA:A0A1R3Y224"
                     /db_xref="InterPro:IPR004435"
                     /db_xref="InterPro:IPR005654"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y224"
BEGIN
        1 MTLIAARRYS ATMHGSASEA CGSVDHLVDR HPTVSPVRLI AQLRPPPTFA EVSFATYRPD
       61 PVEPTQAAAV VACQDFCRQA VERRAGRKKW FGKRDVLPGV GLYLDGGFGV GKTHLLASAY
      121 YQLPGTGPDA PTCPKAFATF GELTQLAGVF GFADCIDLLA NYTALCIDEF ELDDPGNTTL
      181 ISRLLSALVE RGVSVAATSN TLPEQLGEGR FAAQDFLREI NTLASIFTTV RIEGPDYRHR
      241 DLPPAPAPLS DEEVAARAAR VEGATLDDFD ALCAHLATMH PSRYLTLIEG VTAVFLTGVH
      301 GIDDQNVALR LVALVDRLYD AGIPVVASGA KLDTIFSEEM LAGGYRKKYL RATSRLLALT
      361 AGVIQAREP
//