LOCUS       SIU01293.1               126 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ARSR-FAMILY)
            protein.
ACCESSION   LT708304-2707
PROTEIN_ID  SIU01293.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2675"
                     /note="Mb2675, -, len: 126 aa. Equivalent to Rv2642, len:
                     126 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 126 aa overlap). Possible
                     transcriptional regulator, arsR family, highly similar to
                     many e.g. Q9X8X8|SCH35.28c PUTATIVE TRANSCRIPTIONAL
                     REGULATOR from Streptomyces coelicolor (122 aa), FASTA
                     scores: opt: 390, E(): 3.7e-19, (56.55% identity in 122 aa
                     overlap); Q9L220|SC1A2.21 PUTATIVE ARSR-FAMILY
                     TRANSCRIPTIONAL from Streptomyces coelicolor (119 aa),
                     FASTA scores: opt: 378, E(): 2.3e-18, (59.8% identity in
                     97 aa overlap); Q9L1V5|SC4A9.07 PUTATIVE ARSR-FAMILY
                     TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor
                     (117 aa), FASTA scores: opt: 359, E(): 4.1e-17, (56.9%
                     identity in 116 aa overlap); P52144|ARR2_ECOLI|ARSR from
                     Escherichia coli (117 aa), FASTA scores: opt: 202, E():
                     1e-06, (39.8% identity in 88 aa overlap); etc. Also
                     similar to downstream ORF P71939|Rv2640c|MTCY441.10c
                     PUTATIVE TRANSCRIPTIONAL REGULATORY PROTEIN from
                     Mycobacterium tuberculosis (119 aa), FASTA scores: opt:
                     237, E(): 5e-09, (38.55% identity in 109 aa overlap); and
                     others from Mycobacterium tuberculosis e.g.
                     O05840|Rv2358|MTCY27.22c. Contains PS00846 Bacterial
                     regulatory proteins, arsR family signature. Contains
                     helix-turn-helix motif at aa 58-79 (Score 1112, +2.97 SD).
                     BELONGS TO THE ARSR FAMILY OF TRANSCRIPTIONAL REGULATORS.
                     Mb2675 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y1T1"
                     /db_xref="InterPro:IPR001845"
                     /db_xref="InterPro:IPR011991"
                     /db_xref="InterPro:IPR018334"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR036390"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1T1"
BEGIN
        1 MSNLHPLPEV ASCVVAPLVR EPLNPPAAAE MAARFKALAD PVRLQLLSSV ASRAGGEACV
       61 CDISAGVEVS QPTISHHLKV LRDAGLLTSR RRASWVYYAV VPEALTVLSN LLSVHADAAP
      121 ALGAPA
//