LOCUS       SIU01291.1               119 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ARSR-FAMILY)
            protein.
ACCESSION   LT708304-2705
PROTEIN_ID  SIU01291.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2673C"
                     /note="Mb2673c, -, len: 119 aa. Equivalent to Rv2640c,
                     len: 119 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 119 aa overlap). Possible
                     transcriptional regulator, arsR family, highly similar to
                     many e.g. Q9L1V5|SC4A9.07 PUTATIVE ARSR-FAMILY
                     TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor
                     (117 aa), FASTA scores: opt: 261, E(): 5.6e-10, (47.75%
                     identity in 103 aa overlap); Q9X8X8|SCH35.28c PUTATIVE
                     TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor
                     (122 aa), FASTA scores: opt: 252, E(): 2.2e-09, (37.05%
                     identity in 116 aa overlap); Q9L220|SC1A2.21 PUTATIVE
                     ARSR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor
                     (119 aa), FASTA scores: opt: 252, E(): 2.2e-09, (37.05%
                     identity in 116 aa overlap); P77295|YGAV_ECOLI|B2667
                     HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Escherichia
                     coli strain K12 (99 aa), FASTA scores: opt: 156, E():
                     0.0023, (34.1% identity in 88 aa overlap); etc. Also
                     similar to upstream ORF P71941|Rv2642|MTCY441.12 PUTATIVE
                     TRANSCRIPTIONAL REGULATORY PROTEIN from Mycobacterium
                     tuberculosis (126 aa), FASTA scores: opt: 237, E(): 2e-08,
                     (38.55% identity in 109 aa overlap). Contains
                     helix-turn-helix motif at aa 59-80 (Score 1166, +3.16 SD).
                     BELONGS TO THE ARSR FAMILY OF TRANSCRIPTIONAL REGULATORS.
                     Mb2673c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y1T4"
                     /db_xref="InterPro:IPR001845"
                     /db_xref="InterPro:IPR011991"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR036390"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1T4"
BEGIN
        1 MPKSLPVIDI SAPVCCAPVA AGPMSDGDAL AVALRLKALA DPARVKIMSY LFSSPAGEQV
       61 SGQLAAALSL SDGTVSHHLA QLRKAGLVIS DRRGMHVFHR VHPEALQALC TVLNPNCCA
//