LOCUS SIU01289.1 148 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Anti- sigma B factor antagonist RsbV protein. ACCESSION LT708304-2703 PROTEIN_ID SIU01289.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2671" /note="Mb2671, -, len: 148 aa. Equivalent to Rv2638, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 148 aa overlap). Conserved hypothetical protein, similar in part to Q9WVX8|RSBV_STRCO|BLDG|SCH5.12c ANTI-SIGMA B FACTOR ANTAGONIST from Streptomyces coelicolor (113 aa), FASTA scores: opt: 162, E(): 0.00066, (31.8% identity in 110 aa overlap); and showing weak similarity with various proteins e.g. O69205 HYPOTHETICAL 13.4 KDA PROTEIN from Actinosynnema pretiosum (subsp. auranticum) (128 aa), FASTA scores: opt: 157, E(): 0.0016, (29.8% identity in 114 aa overlap); Q9RJ93|SCF91.32 PUTATIVE ANTI-SIGMA FACTOR ANTAGONIST from Streptomyces coelicolor (183 aa), FASTA scores: opt: 148, E(): 0.0082, (30.85% identity in 107 aa overlap); etc. Also highly similar to hypothetical proteins from Mycobacterium tuberculosis: O07728|Rv1904|MTCY180.14c (143 aa), FASTA scores: opt: 456, E(): 3.9e-23, (52.8% identity in 125 aa overlap); and Q11035|YD65_MYCTU|Rv1365c|MT1411|MTCY02B10.29c (128 aa), FASTA scores: opt: 435, E(): 8.6e-22, (53.6% identity in 125 aa overlap). Mb2671 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y1T2" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="UniProtKB/TrEMBL:A0A1R3Y1T2" BEGIN 1 MGLITTEPRS SPHPLSPRLV HELGDPHSTL RATTDGSGAA LLIHAGGEID GRNEHLWRQL 61 VTEAAAGVTA PGPLIVDVTG LDFMGCCAFA ALADEAQRCR CRGIDLRLVS HQPIVARIAE 121 AGGLSRVLPI YPTVDTALGK GTAGPARC //