LOCUS       SIU01289.1               148 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Anti-
            sigma B factor antagonist RsbV protein.
ACCESSION   LT708304-2703
PROTEIN_ID  SIU01289.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2671"
                     /note="Mb2671, -, len: 148 aa. Equivalent to Rv2638, len:
                     148 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 148 aa overlap). Conserved
                     hypothetical protein, similar in part to
                     Q9WVX8|RSBV_STRCO|BLDG|SCH5.12c ANTI-SIGMA B FACTOR
                     ANTAGONIST from Streptomyces coelicolor (113 aa), FASTA
                     scores: opt: 162, E(): 0.00066, (31.8% identity in 110 aa
                     overlap); and showing weak similarity with various
                     proteins e.g. O69205 HYPOTHETICAL 13.4 KDA PROTEIN from
                     Actinosynnema pretiosum (subsp. auranticum) (128 aa),
                     FASTA scores: opt: 157, E(): 0.0016, (29.8% identity in
                     114 aa overlap); Q9RJ93|SCF91.32 PUTATIVE ANTI-SIGMA
                     FACTOR ANTAGONIST from Streptomyces coelicolor (183 aa),
                     FASTA scores: opt: 148, E(): 0.0082, (30.85% identity in
                     107 aa overlap); etc. Also highly similar to hypothetical
                     proteins from Mycobacterium tuberculosis:
                     O07728|Rv1904|MTCY180.14c (143 aa), FASTA scores: opt:
                     456, E(): 3.9e-23, (52.8% identity in 125 aa overlap); and
                     Q11035|YD65_MYCTU|Rv1365c|MT1411|MTCY02B10.29c (128 aa),
                     FASTA scores: opt: 435, E(): 8.6e-22, (53.6% identity in
                     125 aa overlap). Mb2671 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y1T2"
                     /db_xref="InterPro:IPR002645"
                     /db_xref="InterPro:IPR003658"
                     /db_xref="InterPro:IPR036513"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1T2"
BEGIN
        1 MGLITTEPRS SPHPLSPRLV HELGDPHSTL RATTDGSGAA LLIHAGGEID GRNEHLWRQL
       61 VTEAAAGVTA PGPLIVDVTG LDFMGCCAFA ALADEAQRCR CRGIDLRLVS HQPIVARIAE
      121 AGGLSRVLPI YPTVDTALGK GTAGPARC
//