LOCUS SIU01276.1 393 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE CONSERVED TRANSMEMBRANE ALANINE AND LEUCINE RICH PROTEIN protein. ACCESSION LT708304-2690 PROTEIN_ID SIU01276.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2658C" /note="Mb2658c, -, len: 393 aa. Equivalent to Rv2625c, len: 393 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 393 aa overlap). Probable conserved transmembrane ala-, leu-rich protein, similar to many hypothetical or membrane proteins e.g. Q55518|Y528_SYNY3|SLL0528 POTENTIAL INTEGRAL MEMBRANE PROTEIN from Synechocystis sp. strain PCC 6803 (379 aa), FASTA scores: opt: 552, E(): 5.6e-26, (30.75% identity in 374 aa overlap); Q9RJ56|SCI41.35c HYPOTHETICAL 39.8 KDA PROTEIN from Streptomyces coelicolor (374 aa), FASTA scores: opt: 419, E(): 5.7e-18, (31.6% identity in 383 aa overlap); CAC49448|SMB20925 CONSERVED HYPOTHETICAL MEMBRANE PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (372 aa), FASTA scores: opt: 401, E(): 6.9e-17, (29.5% identity in 383 aa overlap); etc. Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Protein product from Mb2658c detected using SWATH mass spectrometry. Mb2658c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y2K2" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR016483" /db_xref="UniProtKB/TrEMBL:A0A1R3Y2K2" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MRDAIPLGRI AGFVVNVHWS VLVILWLFTW SLATMLPGTV GGYPAVVYWL LGAGGAVMLL 61 ASLLAHELAH AVVARRAGVS VESVTLWLFG GVTALGGEAK TPKAAFRIAF AGPATSLALS 121 ATFGALAITL AGVRTPAIVI SVAWWLATVN LLLGLFNLLP GAPLDGGRLV RAYLWRRHGD 181 SVRAGIGAAR AGRVVALVLI ALGLAEFVAG GLVGGVWLAF IGWFIFAAAR EEETRISTQQ 241 LFAGVRVADA MTAQPHTAPG WINVEDFIQR YVLGERHSAY PVADRDGSIT GLVALRQLRD 301 VAPSRRSTTS VGDIALPLHS VPTARPQEPL TALLERMAPL GPRSRALVTE GSAVVGIVTP 361 SDVARLIDVY RLAQPEPTFT TSPQDADRFS DAG //