LOCUS       SIU01266.1               464 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 pe-
            pgrs family protein pe_pgrs45 protein.
ACCESSION   LT708304-2680
PROTEIN_ID  SIU01266.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="PE_PGRS45"
                     /locus_tag="BQ2027_MB2648C"
                     /note="Mb2648c, PE_PGRS45, len: 464 aa. Equivalent to
                     Rv2615c, len: 461 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (98.7% identity in 464 aa overlap). Member
                     of the Mycobacterium tuberculosis PE family, PGRS
                     subfamily of gly-rich proteins, highly similar to many
                     e.g. P71664|Rv1396c|MTCY21B4.13c from Mycobacterium
                     tuberculosis (576 aa), FASTA scores: opt: 1629, E():
                     4.8e-58, (56.65% identity in 482 aa overlap). Equivalent
                     to AAK47006 from Mycobacterium tuberculosis strain CDC1551
                     (476 aa) but shorter 15 aa. REMARK-M.bovis-M.tuberculosis:
                     In Mycobacterium bovis, a 9 bp in-frame insertion
                     (*-ccgccgttt) leads to a slightly longer product compared
                     to its homolog in Mycobacterium tuberculosis strain H37Rv
                     (464 aa versus 461 aa). Mb2648c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR000084"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y2J2"
BEGIN
        1 MSFVNVAPQL VSTAAADAAR IGSAINTANT AAAATTQVLV AAQDEVSTAI AALFGSHGQH
       61 YQAISAQVAA YQERFVLALS QAGSTYAVAE AASATPLQNV LDAINAPVQS LTGRPLIGDG
      121 ANGIDGTGQA GGNGGWLWGN GGNSGSGAPG QAGGAGGAAG LIGNGGAGGA GGQGLPFEAG
      181 ANGGAGGAGG WLFGNGGAGG NGGIGGAGTN LAIGGHGGNG GNAGLIGAGG TGGAGGTGGG
      241 EPSAGASGGN GGNGGNGGLL IGNSGDGGAA GNGAGISQNG PASGFGGNGG HAGTTGLIGN
      301 GGNGGAGGAG GDVSADFGGV GFGGQGGNGG AGGLLYGNGG AGGNGGAAGS PGSVTAFGGN
      361 GGSGGSGGNG GNALIGNAGA GGSAGAGGNG ASAGTAGGSG GDGGKGGNGG SVGLIGNGGN
      421 GGNGGNGGAG SLFNGAPGFG GPGGSGGASL LGPPGLAGTN GADG
//