LOCUS SIU01256.1 299 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 possible pyridoxine biosynthesis protein snzp protein. ACCESSION LT708304-2670 PROTEIN_ID SIU01256.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="snzp" /locus_tag="BQ2027_MB2638C" /note="Mb2638c, -, len: 299 aa. Equivalent to Rv2606c, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 299 aa overlap). Conserved hypothetical protein, equivalent to O07145|YQ06_MYCLE|ML0450|MLCL581.12c HYPOTHETICAL 35.6 KDA PROTEIN from Mycobacterium leprae (307 aa), FASTA scores: opt: 1686, E(): 1.5e-95, (89.7% identity in 291 aa overlap). Also highly similar to other hypothetical proteins (or product of pyroA gene) e.g. Q9L286|SCL2.13c HYPOTHETICAL 32.2 KDA PROTEIN from Streptomyces coelicolor (303 aa), FASTA scores: opt: 1461, E(): 7.6e-82, (76.8% identity in 293 aa overlap); O14027|YEM4_SCHPO|SPAC29B12.04 HYPOTHETICAL 31.4 KDA PROTEIN from Schizosaccharomyces pombe (Fission yeast) (296 aa), FASTA scores: opt: 1318, E(): 3.8e-73, (70.35% identity in 290 aa overlap); Q9UW83|PYROA PROTEIN INVOLVED IN PYRIDOXINE BIOSYNTHESIS from Emericella nidulans (Aspergillus nidulans) (see citation below) (304 aa), FASTA scores: opt: 1288, E(): 2.6e-71, (67.9% identity in 302 aa overlap); etc. Protein product from Mb2638c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2638c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P60795" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="UniProtKB/Swiss-Prot:P60795" BEGIN 1 MDPAGNPATG TARVKRGMAE MLKGGVIMDV VTPEQARIAE GAGAVAVMAL ERVPADIRAQ 61 GGVSRMSDPD MIEGIIAAVT IPVMAKVRIG HFVEAQILQT LGVDYIDESE VLTPADYAHH 121 IDKWNFTVPF VCGATNLGEA LRRISEGAAM IRSKGEAGTG DVSNATTHMR AIGGEIRRLT 181 SMSEDELFVA AKELQAPYEL VAEVARAGKL PVTLFTAGGI ATPADAAMMM QLGAEGVFVG 241 SGIFKSGAPE HRAAAIVKAT TFFDDPDVLA KVSRGLGEAM VGINVDEIAV GHRLAQRGW //