LOCUS       SIU01256.1               299 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 possible
            pyridoxine biosynthesis protein snzp protein.
ACCESSION   LT708304-2670
PROTEIN_ID  SIU01256.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="snzp"
                     /locus_tag="BQ2027_MB2638C"
                     /note="Mb2638c, -, len: 299 aa. Equivalent to Rv2606c,
                     len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 299 aa overlap). Conserved
                     hypothetical protein, equivalent to
                     O07145|YQ06_MYCLE|ML0450|MLCL581.12c HYPOTHETICAL 35.6 KDA
                     PROTEIN from Mycobacterium leprae (307 aa), FASTA scores:
                     opt: 1686, E(): 1.5e-95, (89.7% identity in 291 aa
                     overlap). Also highly similar to other hypothetical
                     proteins (or product of pyroA gene) e.g. Q9L286|SCL2.13c
                     HYPOTHETICAL 32.2 KDA PROTEIN from Streptomyces coelicolor
                     (303 aa), FASTA scores: opt: 1461, E(): 7.6e-82, (76.8%
                     identity in 293 aa overlap);
                     O14027|YEM4_SCHPO|SPAC29B12.04 HYPOTHETICAL 31.4 KDA
                     PROTEIN from Schizosaccharomyces pombe (Fission yeast)
                     (296 aa), FASTA scores: opt: 1318, E(): 3.8e-73, (70.35%
                     identity in 290 aa overlap); Q9UW83|PYROA PROTEIN INVOLVED
                     IN PYRIDOXINE BIOSYNTHESIS from Emericella nidulans
                     (Aspergillus nidulans) (see citation below) (304 aa),
                     FASTA scores: opt: 1288, E(): 2.6e-71, (67.9% identity in
                     302 aa overlap); etc. Protein product from Mb2638c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb2638c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P60795"
                     /db_xref="InterPro:IPR001852"
                     /db_xref="InterPro:IPR011060"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="InterPro:IPR033755"
                     /db_xref="UniProtKB/Swiss-Prot:P60795"
BEGIN
        1 MDPAGNPATG TARVKRGMAE MLKGGVIMDV VTPEQARIAE GAGAVAVMAL ERVPADIRAQ
       61 GGVSRMSDPD MIEGIIAAVT IPVMAKVRIG HFVEAQILQT LGVDYIDESE VLTPADYAHH
      121 IDKWNFTVPF VCGATNLGEA LRRISEGAAM IRSKGEAGTG DVSNATTHMR AIGGEIRRLT
      181 SMSEDELFVA AKELQAPYEL VAEVARAGKL PVTLFTAGGI ATPADAAMMM QLGAEGVFVG
      241 SGIFKSGAPE HRAAAIVKAT TFFDDPDVLA KVSRGLGEAM VGINVDEIAV GHRLAQRGW
//