LOCUS       SIU01254.1               198 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            glutamine amidotransferase snop protein.
ACCESSION   LT708304-2668
PROTEIN_ID  SIU01254.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="snop"
                     /locus_tag="BQ2027_MB2636C"
                     /note="Mb2636c, -, len: 198 aa. Equivalent to Rv2604c,
                     len: 198 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 198 aa overlap). Conserved
                     hypothetical protein, equivalent (but shorter 21 aa) to
                     Q49637|HISH|B1177_C1_149 HISH PROTEIN (BELONGS TO THE
                     YFL060C/YAAE/HI1648 FAMILY) (alias Q9CCT5|ML0474
                     HYPOTHETICAL PROTEIN 223 aa) from Mycobacterium leprae
                     (219 aa), FASTA scores: opt: 1069, E(): 1.7e-60, (83.35%
                     identity in 198 aa overlap). Also highly similar to
                     hypothetical proteins or amidotransferases e.g.
                     Q9L287|SCL2.12c HYPOTHETICAL 21.5 KDA PROTEIN from
                     Streptomyces coelicolor (202 aa), FASTA scores: opt: 702,
                     E(): 2.3e-37, (56.75% identity in 192 aa overlap);
                     P37528|YAAE_BACSU HYPOTHETICAL 21.4 KDA PROTEIN from
                     Bacillus subtilis (196 aa), FASTA scores: opt: 608, E():
                     1.9e-31, (48.7% identity in 189 aa overlap); Q9KGN5|BH0023
                     AMIDOTRANSFERASE from Bacillus halodurans (196 aa), FASTA
                     scores: opt: 583, E(): 7.4e-30, (48.7% identity in 195 aa
                     overlap); etc. Also some similarity with several proteins
                     from Mycobacterium tuberculosis e.g.
                     O06589|HIS5_MYCTU|Rv1602|MT1638|MTCY336.02c
                     AMIDOTRANSFERASE (EC 2.4.2.-) (206 aa), FASTA scores: opt:
                     154, E(): 0.00036, (30.6% identity in 193 aa overlap).
                     Protein product from Mb2636c detected using SWATH mass
                     spectrometry. Mb2636c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:Q7TY92"
                     /db_xref="InterPro:IPR002161"
                     /db_xref="InterPro:IPR021196"
                     /db_xref="InterPro:IPR029062"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TY92"
BEGIN
        1 MSVPRVGVLA LQGDTREHLA ALRECGAEPM TVRRRDELDA VDALVIPGGE STTMSHLLLD
       61 LDLLGPLRAR LADGLPAYGS CAGMILLASE ILDAGAAGRQ ALPLRAMNMT VRRNAFGSQV
      121 DSFEGDIEFA GLDDPVRAVF IRAPWVERVG DGVQVLARAA GHIVAVRQGA VLATAFHPEM
      181 TGDRRIHQLF VDIVTSAA
//