LOCUS       SIU01243.1               188 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CROSSOVER JUNCTION ENDODEOXYRIBONUCLEASE RUVC (HOLLIDAY
            JUNCTION NUCLEASE) (HOLLIDAY JUNCTION RESOLVASE) protein.
ACCESSION   LT708304-2657
PROTEIN_ID  SIU01243.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ruvC"
                     /locus_tag="BQ2027_MB2625C"
                     /note="Mb2625c, ruvC, len: 188 aa. Equivalent to Rv2594c,
                     len: 188 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 188 aa overlap). Probable ruvC,
                     Holliday junction resolvase (EC 3.1.22.4) (see citations
                     below), equivalent to
                     P40834|RUVC_MYCLE|ML0481|B1177_C3_226 CROSSOVER JUNCTION
                     ENDODEOXYRIBONUCLEASE from Mycobacterium leprae (188 aa),
                     FASTA scores: opt: 984, E(): 2.3e-55, (81.0% identity in
                     184 aa overlap). Also highly similar to others e.g.
                     Q9AE11|RUVC from Corynebacterium glutamicum
                     (Brevibacterium flavum) (221 aa), FASTA scores: opt: 713,
                     E(): 3.6e-38, (56.9% identity in 188 aa overlap);
                     Q9L289|RUVC_STRCO|SCL2.10c from Streptomyces coelicolor
                     (188 aa), FASTA scores: opt: 704, E(): 1.2e-37, (60.65%
                     identity in 178 aa overlap); P24239|RUVC_ECOLI|B1863 from
                     Escherichia coli strain K12 (172 aa), FASTA scores: opt:
                     322, E(): 1.6e-13, (38.65% identity in 163 aa overlap);
                     etc. BELONGS TO THE RUVC FAMILY. COFACTOR: MAGNESIUM.
                     Mb2625c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:P66761"
                     /db_xref="InterPro:IPR002176"
                     /db_xref="InterPro:IPR012337"
                     /db_xref="InterPro:IPR020563"
                     /db_xref="InterPro:IPR036397"
                     /db_xref="UniProtKB/Swiss-Prot:P66761"
BEGIN
        1 MRVMGVDPGL TRCGLSLIES GRGRQLTALD VDVVRTPSDA ALAQRLLAIS DAVEHWLDTH
       61 HPEVVAIERV FSQLNVTTVM GTAQAGGVIA LAAAKRGVDV HFHTPSEVKA AVTGNGSADK
      121 AQVTAMVTKI LALQAKPTPA DAADALALAI CHCWRAPTIA RMAEATSRAE ARAAQQRHAY
      181 LAKLKAAR
//