LOCUS       SIU01232.1               790 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            GTP PYROPHOSPHOKINASE RELA (ATP:GTP 3'-PYROPHOSPHOTRANSFERASE)
            (PPGPP SYNTHETASE I) ((P)PPGPP SYNTHETASE) (GTP DIPHOSPHOKINASE)
            protein.
ACCESSION   LT708304-2646
PROTEIN_ID  SIU01232.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="relA"
                     /locus_tag="BQ2027_MB2614C"
                     /note="Mb2614c, relA, len: 790 aa. Equivalent to Rv2583c,
                     len: 790 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 790 aa overlap). Probable relA, GTP
                     pyrophosphokinase (EC 2.7.6.5), equivalent to
                     Q49640|RELA_MYCLE|ML0491|MLCB1259.09|B1177_C1_168 PROBABLE
                     GTP PYROPHOSPHOKINASE from Mycobacterium leprae (787 aa),
                     FASTA scores: opt: 4834, E(): 0, (93.4% identity in 790 aa
                     overlap). Also highly similar to others e.g.
                     O87331|RELA_CORGL|RELA|REL from Corynebacterium glutamicum
                     (Brevibacterium flavum) (760 aa), FASTA scores: opt: 3375,
                     E(): 1.6e-196, (67.0% identity in 758 aa overlap);
                     O85709|RELA_STRAT from Streptomyces antibioticus (841 aa),
                     FASTA scores: opt: 3209, E(): 1.9e-186, (63.85% identity
                     in 786 aa overlap); Q9KDH1|RELA|BH1242 from Bacillus
                     halodurans (728 aa), FASTA scores: opt: 2195,E():
                     3.8e-125, (45.65% identity in 714 aa overlap); etc.
                     BELONGS TO THE RELA / SPOT FAMILY. Protein product from
                     Mb2614c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb2614c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P66015"
                     /db_xref="InterPro:IPR002912"
                     /db_xref="InterPro:IPR003607"
                     /db_xref="InterPro:IPR004095"
                     /db_xref="InterPro:IPR004811"
                     /db_xref="InterPro:IPR007685"
                     /db_xref="InterPro:IPR012675"
                     /db_xref="InterPro:IPR012676"
                     /db_xref="InterPro:IPR033655"
                     /db_xref="UniProtKB/Swiss-Prot:P66015"
BEGIN
        1 MAEDQLTAQA VAPPTEASAA LEPALETPES PVETLKTSIS ASRRVRARLA RRMTAQRSTT
       61 NPVLEPLVAV HREIYPKADL SILQRAYEVA DQRHASQLRQ SGDPYITHPL AVANILAELG
      121 MDTTTLVAAL LHDTVEDTGY TLEALTEEFG EEVGHLVDGV TKLDRVVLGS AAEGETIRKM
      181 ITAMARDPRV LVIKVADRLH NMRTMRFLPP EKQARKARET LEVIAPLAHR LGMASVKWEL
      241 EDLSFAILHP KKYEEIVRLV AGRAPSRDTY LAKVRAEIVN TLTASKIKAT VEGRPKHYWS
      301 IYQKMIVKGR DFDDIHDLVG VRILCDEIRD CYAAVGVVHS LWQPMAGRFK DYIAQPRYGV
      361 YQSLHTTVVG PEGKPLEVQI RTRDMHRTAE YGIAAHWRYK EAKGRNGVLH PHAAAEIDDM
      421 AWMRQLLDWQ REAADPGEFL ESLRYDLAVQ EIFVFTPKGD VITLPTGSTP VDFAYAVHTE
      481 VGHRCIGARV NGRLVALERK LENGEVVEVF TSKAPNAGPS RDWQQFVVSP RAKTKIRQWF
      541 AKERREEALE TGKDAMAREV RRGGLPLQRL VNGESMAAVA RELHYADVSA LYTAIGEGHV
      601 SAKHVVQRLL AELGGIDQAE EELAERSTPA TMPRRPRSTD DVGVSVPGAP GVLTKLAKCC
      661 TPVPGDVIMG FVTRGGGVSV HRTDCTNAAS LQQQAERIIE VLWAPSPSSV FLVAIQVEAL
      721 DRHRLLSDVT RALADEKVNI LSASVTTSGD RVAISRFTFE MGDPKHLGHL LNAVRNVEGV
      781 YDVYRVTSAA
//