LOCUS SIU01221.1 276 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 2-dehydropantoate 2-reductase (EC protein. ACCESSION LT708304-2635 PROTEIN_ID SIU01221.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2603" /EC_number="1.1.1.169" /note="Mb2603, -, len: 246 aa. Equivalent to Rv2573, len: 246 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 246 aa overlap). Conserved hypothetical protein, similar to various proteins e.g. Q9ABG6|CC0261 HYPOTHETICAL PROTEIN from Caulobacter crescentus (290 aa), FASTA scores: opt: 516, E(): 5.8e-26, (40.1% identity in 237 aa overlap); Q99R37|SA2393 HYPOTHETICAL PROTEIN (similar to 2-dehydropantoate 2-reductase) from Staphylococcus aureus subsp. aureus N315 (286 aa), FASTA scores: opt: 368, E(): 1.8e-16, (31.75% identity in 230 aa overlap); Q9KPQ9|VC2307 2-DEHYDROPANTOATE 2-REDUCTASE from Vibrio cholerae (296 aa), FASTA scores: opt: 223, E(): 3.9e-07, (27.7% identity in 224 aa overlap); etc. Equivalent to AAK46962 from Mycobacterium tuberculosis strain CDC1551 (275 aa) but shorter 29 aa. Mb2603 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y1L0" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="UniProtKB/TrEMBL:A0A1R3Y1L0" BEGIN 1 MLHKAGYSPL LCGHTPRAGI ELRRDGADPI VVPGPVHTSP REVAGPVDVL ILAVKATQND 61 AARPWLTRLC DERTVVAVLQ NGVEQVEQVQ PHCPSSAVVP AIVWCSAETQ PQGWVRLRGE 121 AALVVPTGPA AEQFAGLLRG AGATVDCDPD FTTAAWRKLL VNALAGFMVL SGRRSAMFRR 181 DDVAALSRRY VAECLAVARA EGARLDDDVV DEVVRLVRSA PQDMGTSMLA DRAAHRPLEW 241 DLRNGVIVRK ARAHGLATPI SDVLVPLLAA ASDGPG //