LOCUS       SIU01221.1               276 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 2-dehydropantoate
            2-reductase (EC protein.
ACCESSION   LT708304-2635
PROTEIN_ID  SIU01221.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2603"
                     /EC_number="1.1.1.169"
                     /note="Mb2603, -, len: 246 aa. Equivalent to Rv2573, len:
                     246 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 246 aa overlap). Conserved
                     hypothetical protein, similar to various proteins e.g.
                     Q9ABG6|CC0261 HYPOTHETICAL PROTEIN from Caulobacter
                     crescentus (290 aa), FASTA scores: opt: 516, E(): 5.8e-26,
                     (40.1% identity in 237 aa overlap); Q99R37|SA2393
                     HYPOTHETICAL PROTEIN (similar to 2-dehydropantoate
                     2-reductase) from Staphylococcus aureus subsp. aureus N315
                     (286 aa), FASTA scores: opt: 368, E(): 1.8e-16, (31.75%
                     identity in 230 aa overlap); Q9KPQ9|VC2307
                     2-DEHYDROPANTOATE 2-REDUCTASE from Vibrio cholerae (296
                     aa), FASTA scores: opt: 223, E(): 3.9e-07, (27.7% identity
                     in 224 aa overlap); etc. Equivalent to AAK46962 from
                     Mycobacterium tuberculosis strain CDC1551 (275 aa) but
                     shorter 29 aa. Mb2603 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y1L0"
                     /db_xref="InterPro:IPR003710"
                     /db_xref="InterPro:IPR008927"
                     /db_xref="InterPro:IPR013328"
                     /db_xref="InterPro:IPR013332"
                     /db_xref="InterPro:IPR013752"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1L0"
BEGIN
        1 MLHKAGYSPL LCGHTPRAGI ELRRDGADPI VVPGPVHTSP REVAGPVDVL ILAVKATQND
       61 AARPWLTRLC DERTVVAVLQ NGVEQVEQVQ PHCPSSAVVP AIVWCSAETQ PQGWVRLRGE
      121 AALVVPTGPA AEQFAGLLRG AGATVDCDPD FTTAAWRKLL VNALAGFMVL SGRRSAMFRR
      181 DDVAALSRRY VAECLAVARA EGARLDDDVV DEVVRLVRSA PQDMGTSMLA DRAAHRPLEW
      241 DLRNGVIVRK ARAHGLATPI SDVLVPLLAA ASDGPG
//