LOCUS       SIU01220.1               611 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            aspartyl-trna synthetase asps (aspartate--trna ligase)
            (asprs) (aspartic acid translase) protein.
ACCESSION   LT708304-2634
PROTEIN_ID  SIU01220.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="aspS"
                     /locus_tag="BQ2027_MB2602C"
                     /note="Mb2602c, aspS, len: 611 aa. Equivalent to Rv2572c,
                     len: 596 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 595 aa overlap). Probable aspS,
                     aspartyl-tRNA synthetase (EC 6.1.1.12), equivalent to
                     P36429|SYD_MYCLE|ML0501|MLCB1259.19 ASPARTYL-TRNA
                     SYNTHETASE from Mycobacterium leprae (589 aa), FASTA
                     scores: opt: 3534, E(): 1.8e-215, (87.85% identity in 592
                     aa overlap). Also highly similar to many e.g.
                     O67589|SYD_AQUAE|AQ_1677 from Aquifex aeolicus (603 aa),
                     FASTA scores: opt: 1829, E(): 8.2e-108, (47.5% identity in
                     598 aa overlap); O32038|SYD_BACSU from Bacillus subtilis
                     (592 aa), FASTA scores: opt: 1732, E(): 1.1e-101, (46.25%
                     identity in 597 aa overlap); P21889|SYD_ECOLI|TLS|B1866
                     from Escherichia coli strain K12 (590 aa), FASTA scores:
                     opt: 1588, E(): 1.3e-92, (47.35% identity in 581 aa
                     overlap); etc. Contains PS00179 Aminoacyl-transfer RNA
                     synthetases class-II signature 1. BELONGS TO CLASS-II
                     AMINOACYL-TRNA SYNTHETASE FAMILY.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
                     single base deletion (t-*) omitting a stop codon, leads to
                     a longer protein with a different COOH end compared to its
                     homolog in Mycobacterium tuberculosis strain H37Rv (611 aa
                     versus 596 aa). Protein product from Mb2602c detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb2602c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:Q7TYA6"
                     /db_xref="InterPro:IPR002312"
                     /db_xref="InterPro:IPR004115"
                     /db_xref="InterPro:IPR004364"
                     /db_xref="InterPro:IPR004365"
                     /db_xref="InterPro:IPR004524"
                     /db_xref="InterPro:IPR006195"
                     /db_xref="InterPro:IPR012340"
                     /db_xref="InterPro:IPR029351"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TYA6"
BEGIN
        1 MFVLRSHAAG LLREGDAGQQ VTLAGWVARR RDHGGVIFID LRDASGIAQV VFRDPQDTEV
       61 LAQAHRLRAE FCVSVAGVVE IRPEGNANPE IATGEIEVNA TSLTVLGECA PLPFQLDEPA
      121 GEELRLKYRY LDLRRDDPAA AIRLRSRVNA AARAVLARHD FVEIETPTIT RSTPEGARDF
      181 LVPARLHPGS FYALPQSPQL FKQLLMVAGM ERYYQIARCY RDEDFRADRQ PEFTQLDMEM
      241 SFVDAEDIIA ISEEVLTELW ALIGYRIPTP IPRIGYAEAM RRFGTDKPDL RFGLELVECT
      301 DFFSDTTFRV FQAPYVGAVV MPGGASQPRR TLDGWQDWAK QRGHRGLAYV LVAEDGTLGG
      361 PVAKNLTEAE RTGLADHVGA KPGDCIFFSA GPVKSSRALL GAARVEIANR LGLIDPDAWA
      421 FVWVVDPPLF EPADEATAAG EVAVGSGAWT AVHHAFTAPK PEWEDRIESD TGSVLADAYD
      481 IVCNGHEIGG GSVRIHRRDI QERVFAVMGL DKAEVEEKFG FLLEAFMFGA PPHGGIAFGW
      541 DRTTALLAGM DSIREVIAFP KTGGGVDPLT DAPAPITAQQ RKESGIDAQP KRVQRHDQIF
      601 AVTTSHPSVN K
//