LOCUS SIU01212.1 583 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Predicted
esterase of the alpha-beta hydrolase superfamily protein.
ACCESSION LT708304-2626
PROTEIN_ID SIU01212.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/locus_tag="BQ2027_MB2594"
/note="Mb2594, -, len: 583 aa. Equivalent to Rv2565, len:
583 aa, from Mycobacterium tuberculosis strain H37Rv,
(100.0% identity in 583 aa overlap). Conserved
hypothetical protein, similar in part to Q9A6C3|CC2171
HYPOTHETICAL PROTEIN from Caulobacter crescentus (610 aa),
FASTA scores: opt: 765, E(): 2.8e-37, (32.15% identity in
575 aa overlap). C-terminus also highly similar to various
bacterial proteins e.g. O34731|YLBK_BACSU HYPOTHETICAL
28.3 KDA PROTEIN from Bacillus subtilis (260 aa), FASTA
scores: opt: 386, E(): 2.2e-15, (33.05% identity in 245 aa
overlap); CAC45997|SMC01003 CONSERVED HYPOTHETICAL PROTEIN
from Rhizobium meliloti (Sinorhizobium meliloti) (321 aa),
FASTA scores: opt: 352, E(): 2.5e-13, (29.65% identity in
280 aa overlap); Q9K9Q8|BH2587 HYPOTHETICAL PROTEIN from
Bacillus halodurans (275 aa), FASTA scores: opt: 334, E():
2.5e-12, (33.7% identity in 175 aa overlap); etc. And
shows similarity to C-terminal half of some eukaryotic
proteins e.g. Q9R114|NTE NEUROPATHY TARGET ESTERASE
HOMOLOG from Mus musculus (Mouse) (1327 aa), FASTA scores:
opt: 411, E(): 2.7e-16, (24.45% identity in 626 aa
overlap); O60859 NEUROPATHY TARGET ESTERASE from Homo
sapiens (Human) (1327 aa), FASTA scores: opt: 410, E():
3.1e-16, (24.1% identity in 627 aa overlap);
Q9U969|SWS|CG2212 SWISS CHEESE PROTEIN from Drosophila
melanogaster (Fruit fly) (1425 aa), FASTA scores: opt:
401, E(): 1.1e-15, (27.75% identity in 544 aa overlap);
etc. Also shows strong similarity to C-terminal half of
O05884|Z95121|Rv3239c|MTY20B11.14c HYPOTHETICAL 110.2 KDA
PROTEIN from Mycobacterium tuberculosis (1048 aa), FASTA
scores: opt: 648, E(): 3e-30, (36.55% identity in 572 aa
overlap); and O69695|Rv3728|MTV025.076 PUTATIVE TWO-DOMAIN
MEMBRANE PROTEIN from Mycobacterium tuberculosis (1065
aa), FASTA scores: opt: 643, E(): 6e-30, (34.3% identity
in 595 aa overlap). Protein product from Mb2594 detected
using shotgun mass spectrometry and SWATH mass
spectrometry. Mb2594 found to be expressed during
exponential growth in Sauton's minimal media by
RNA-sequencing."
/db_xref="GOA:P0A643"
/db_xref="InterPro:IPR000595"
/db_xref="InterPro:IPR001423"
/db_xref="InterPro:IPR002641"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR018490"
/db_xref="UniProtKB/Swiss-Prot:P0A643"
BEGIN
1 MTTARRRPKR RGTDARTALR NVPILADIDD EQLERLATTV ERRHVPANQW LFHAGEPADS
61 IYIVDSGRFV AVAPEGHVFA EMASGDSIGD LGVIAGAARS AGVRALRDGV VWRIAAETFT
121 DMLEATPLLQ SAMLRAMARM LRQSRPAKTA RRPRVIGVVS NGDTAAAPMV DAIATSLDSH
181 GRTAVIAPPV ETTSAVQEYD ELVEAFSETL DRAERSNDWV LVVADRGAGD LWRHYVSAQS
241 DRLVVLVDQR YPPDAVDSLA TQRPVHLITC LAEPDPSWWD RLAPVSHHPA NSDGFGALAR
301 RIAGRSLGLV MAGGGARGLA HFGVYQELTE AGVVIDRFGG TSSGAIASAA FALGMDAGDA
361 IAAAREFIAG SDPLGDYTIP ISALTRGGRV DRLVQGFFGN TLIEHLPRGF FSVSADMITG
421 DQIIHRRGSV SGAVRASISI PGLIPPVHNG EQLLVDGGLL NNLPANVMCA DTDGEVICVD
481 LRRTFVPSKG FGLLPPIVTP PGLLRRLLTG TDNALPPLQE TLLRAFDLAA STANLRELPR
541 VAAIIEPDVS KIGVLNFKQI DAALEAGRMA ARAALQAQPD LVR
//