LOCUS SIU01211.1 330 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE GLUTAMINE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER GLNQ protein. ACCESSION LT708304-2625 PROTEIN_ID SIU01211.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="glnQ" /locus_tag="BQ2027_MB2593" /note="Mb2593, glnQ, len: 330 aa. Equivalent to Rv2564, len: 330 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 330 aa overlap). Probable glnQ, glutamine-transport ATP-binding protein ABC transporter (see citation below), highly similar to many e.g. Q9L0J9|SCD40A.12c PUTATIVE ABC-TRANSPORTER ATP-BINDING PROTEIN from Streptomyces coelicolor (246 aa), FASTA scores: opt: 598, E(): 2.5e-26, (46.35% identity in 218 aa overlap); O54136|SC2E9.11 from Streptomyces coelicolor (230 aa), FASTA scores: opt: 592, E(): 5.1e-26, (46.55% identity in 219 aa overlap); O29244|AF1018 from Archaeoglobus fulgidus (228 aa), FASTA scores: opt: 580, E(): 2.4e-25, (42.4% identity in 210 aa overlap); P75831|YBJZ_ECOLI|B0879 from Escherichia coli strain K12 (648 aa), FASTA scores: opt: 555, E(): 1.3e-23, (39.65% identity in 232 aa overlap); etc. Also highly similar to O53618|Rv0073|MTV030.17 ABC-TRANSPORTER ATP-BINDING SUBUNIT from Mycobacterium tuberculosis (330 aa), FASTA scores: opt: 1782, E(): 4.7e-92, (83.65% identity in 330 aa overlap); etc. Shows some similarity to Q11040|YC81_MYCTU|MTCY50.01|Rv1281c|MT1318 HYPOTHETICAL ABC TRANSPORTER ATP-BINDING PROTEIN from Mycobacterium tuberculosis (612 aa) (32.9 % identity in 234 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and PS00889 Cyclic nucleotide-binding domain signature 2. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Protein product from Mb2593 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2593 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P63402" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR018488" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR027417" /db_xref="UniProtKB/Swiss-Prot:P63402" BEGIN 1 MGGLTISDLV VEYSSGGYAV RPIDGLSLDV APGSLVILLG PSGCGKTTLL SCLGGILRPK 61 SGSIKFDDVD ITTLEGAALA KYRRDKVGIV FQAFNLVSSL TALENVMVPL RAAGVSRAAA 121 RKRAEDLLIR VNLGERMKHR PGDMSGGQQQ RVAVARAIAL DPQLILADEP TAHLDFIQVE 181 EVLRLIRSLA QGDRVVVVAT HDSRMLPLAD RVLELMPAQV SPNQPPETVH VKAGEVLFEQ 241 STMGDLIYVV SEGEFEIVRE LADGGEELVK TAAPGDYFGE IGVLFHLPRS ATVRARSDAT 301 AVGYTAQAFR ERLGVTRVAD LIEHRELASE //