LOCUS       SIU01211.1               330 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            GLUTAMINE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER
            GLNQ protein.
ACCESSION   LT708304-2625
PROTEIN_ID  SIU01211.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="glnQ"
                     /locus_tag="BQ2027_MB2593"
                     /note="Mb2593, glnQ, len: 330 aa. Equivalent to Rv2564,
                     len: 330 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 330 aa overlap). Probable glnQ,
                     glutamine-transport ATP-binding protein ABC transporter
                     (see citation below), highly similar to many e.g.
                     Q9L0J9|SCD40A.12c PUTATIVE ABC-TRANSPORTER ATP-BINDING
                     PROTEIN from Streptomyces coelicolor (246 aa), FASTA
                     scores: opt: 598, E(): 2.5e-26, (46.35% identity in 218 aa
                     overlap); O54136|SC2E9.11 from Streptomyces coelicolor
                     (230 aa), FASTA scores: opt: 592, E(): 5.1e-26, (46.55%
                     identity in 219 aa overlap); O29244|AF1018 from
                     Archaeoglobus fulgidus (228 aa), FASTA scores: opt: 580,
                     E(): 2.4e-25, (42.4% identity in 210 aa overlap);
                     P75831|YBJZ_ECOLI|B0879 from Escherichia coli strain K12
                     (648 aa), FASTA scores: opt: 555, E(): 1.3e-23, (39.65%
                     identity in 232 aa overlap); etc. Also highly similar to
                     O53618|Rv0073|MTV030.17 ABC-TRANSPORTER ATP-BINDING
                     SUBUNIT from Mycobacterium tuberculosis (330 aa), FASTA
                     scores: opt: 1782, E(): 4.7e-92, (83.65% identity in 330
                     aa overlap); etc. Shows some similarity to
                     Q11040|YC81_MYCTU|MTCY50.01|Rv1281c|MT1318 HYPOTHETICAL
                     ABC TRANSPORTER ATP-BINDING PROTEIN from Mycobacterium
                     tuberculosis (612 aa) (32.9 % identity in 234 aa overlap).
                     Contains PS00017 ATP/GTP-binding site motif A (P-loop),
                     PS00211 ABC transporters family signature, and PS00889
                     Cyclic nucleotide-binding domain signature 2. BELONGS TO
                     THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC
                     TRANSPORTERS). Protein product from Mb2593 detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb2593 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:P63402"
                     /db_xref="InterPro:IPR000595"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="InterPro:IPR017871"
                     /db_xref="InterPro:IPR018488"
                     /db_xref="InterPro:IPR018490"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/Swiss-Prot:P63402"
BEGIN
        1 MGGLTISDLV VEYSSGGYAV RPIDGLSLDV APGSLVILLG PSGCGKTTLL SCLGGILRPK
       61 SGSIKFDDVD ITTLEGAALA KYRRDKVGIV FQAFNLVSSL TALENVMVPL RAAGVSRAAA
      121 RKRAEDLLIR VNLGERMKHR PGDMSGGQQQ RVAVARAIAL DPQLILADEP TAHLDFIQVE
      181 EVLRLIRSLA QGDRVVVVAT HDSRMLPLAD RVLELMPAQV SPNQPPETVH VKAGEVLFEQ
      241 STMGDLIYVV SEGEFEIVRE LADGGEELVK TAAPGDYFGE IGVLFHLPRS ATVRARSDAT
      301 AVGYTAQAFR ERLGVTRVAD LIEHRELASE
//