LOCUS SIU01210.1 349 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE GLUTAMINE-TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER protein. ACCESSION LT708304-2624 PROTEIN_ID SIU01210.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2592" /note="Mb2592, -, len: 349 aa. Equivalent to Rv2563, len: 349 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 349 aa overlap). Probable glutamine-transport transmembrane protein ABC transporter (see citation below), highly similar to O53617|Rv0072|MTV030.16 PUTATIVE ABC-TRANSPORTER TRANSMEMBRANE SUBUNIT from Mycobacterium tuberculosis (349 aa), FASTA scores: opt: 1772, E(): 1.1e-89, (76.2% identity in 349 aa overlap). Also some similarity with various hypothetical proteins e.g. Q9RYN1|DRA0279 HYPOTHETICAL 37.1 KDA PROTEIN from Deinococcus radiodurans (353 aa), FASTA scores: opt: 347, E(): 6.6e-12, (24.35% identity in 357 aa overlap); BAB58522|SAV2360 CONSERVED HYPOTHETICAL PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (351 aa), FASTA scores: opt: 262, E(): 2.9e-07, (19.4% identity in 356 aa overlap); Q9AK94|SC10A9.10c PUTATIVE ABC TRANSPORT SYSTEM TRANSMEMBRANE PROTEIN from Streptomyces coelicolor (379 aa), FASTA scores: opt: 172, E(): 0.025, (26.85% identity in 387 aa overlap); etc. Protein product from Mb2592 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2592 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P65008" /db_xref="UniProtKB/Swiss-Prot:P65008" BEGIN 1 MLFAALRDVQ WRKRRLVIAI VSTGLVFAMT LVLTGLVNGF RVEAERTVDS MGVDAFVVKA 61 GAAGPFLGST PFAQIDLPQV ARAPGVLAAA PLATAPSTIR QGTSARNVTA FGAPEHGPGM 121 PRVSDGRAPS TPDEVAVSST LGRNLGDDLQ VGARTLRIVG IVPESTALAK IPNIFLTTEG 181 LQQLAYNGQP TISSIGIDGM PRQLPDGYQT VNRADAVSDL MRPLKVAVDA ITVVAVLLWI 241 VAALIVGSVV YLSALERLRD FAVFKAIGVP TRSILAGLAL QAVVVALLAA VVGGILSLLL 301 APLFPMTVVV PLSAFVALPA IATVIGLLAS VAGLRRVVAI DPALAFGGP //