LOCUS SIU01203.1 904 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE ALANYL-TRNA SYNTHETASE ALAS (ALANINE--TRNA LIGASE) (ALANINE TRANSLASE) (ALARS) protein. ACCESSION LT708304-2617 PROTEIN_ID SIU01203.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="alaS" /locus_tag="BQ2027_MB2585C" /note="Mb2585c, alaS, len: 904 aa. Equivalent to Rv2555c, len: 904 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 904 aa overlap). Probable alaS, alanyl-tRNA synthetase (EC 6.1.1.7), equivalent to Q9CCT0|ALAS|ML0512 ALANYL-TRNA SYNTHETASE from Mycobacterium leprae (908 aa), FASTA scores: opt: 5013, E(): 0, (84.65% identity in 907 aa overlap). Also highly similar to many e.g. Q9KXP9|ALAS from Streptomyces coelicolor (890 aa), FASTA scores: opt: 2159, E(): 3.8e-118, (53.45% identity in 907 aa overlap); Q9FFC7 Arabidopsis thaliana (Mouse-ear cress) (954 aa), FASTA scores: opt: 1963, E(): 1.1e-106, (41.1% identity in 925 aa overlap); Q9RS27|DR2300 from Deinococcus radiodurans (890 aa), FASTA scores: opt: 1352, E(): 4.1e-71, (38.05% identity in 915 aa overlap); etc. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY. Protein product from Mb2585c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2585c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:Q7TYB1" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="UniProtKB/Swiss-Prot:Q7TYB1" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MQTHEIRKRF LDHFVKAGHT EVPSASVILD DPNLLFVNAG MVQFVPFFLG QRTPPYPTAT 61 SIQKCIRTPD IDEVGITTRH NTFFQMAGNF SFGDYFKRGA IELAWALLTN SLAAGGYGLD 121 PERIWTTVYF DDDEAVRLWQ EVAGLPAERI QRRGMADNYW SMGIPGPCGP SSEIYYDRGP 181 EFGPAGGPIV SEDRYLEVWN LVFMQNERGE GTTKEDYQIL GPLPRNNIDT GMGVERIALV 241 LQDVHNVYET DLLRPVIDTV ARVAARAYDV GNHEDDVRYR IIADHSRTAA ILIGDGVSPG 301 NDGRGYVLRR LLRRVIRSAK LLGIDAAIVG DLMATVRNAM GPSYPELVAD FERISRIAVA 361 EETAFNRTLA SGSRLFEEVA SSTKKSGATV LSGSDAFTLH DTYGFPIELT LEMAAETGLQ 421 VDEIGFRELM AEQRRRAKAD AAARKHAHAD LSAYRELVDA GATEFTGFDE LRSQARILGI 481 FVDGKRVPVV AHGVAGGAGE GQRVELVLDR TPLYAESGGQ IADEGTISGT GSSEAARAAV 541 TDVQKIAKTL WVHRVNVESG EFVEGDTVIA AVDPGWRRGA TQGHSGTHMV HAALRQVLGP 601 NAVQAGSLNR PGYLRFDFNW QGPLTDDQRT QVEEVTNEAV QADFEVRTFT EQLDKAKAMG 661 AIALFGESYP DEVRVVEMGG PFSLELCGGT HVSNTAQIGP VTILGESSIG SGVRRVEAYV 721 GLDSFRHLAK ERALMAGLAS SLKVPSEEVP ARVANLVERL RAAEKELERV RMASARAAAT 781 NAAAGAQRIG NVRLVAQRMS GGMTAADLRS LIGDIRGKLG SEPAVVALIA EGESQTVPYA 841 VAANPAAQDL GIRANDLVKQ LAVAVEGRGG GKADLAQGSG KNPTGIDAAL DAVRSEIAVI 901 ARVG //