LOCUS       SIU01184.1               362 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 3-DEHYDROQUINATE 
            SYNTHASE AROB protein.
ACCESSION   LT708304-2598
PROTEIN_ID  SIU01184.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="aroB"
                     /locus_tag="BQ2027_MB2567C"
                     /note="Mb2567c, aroB, len: 362 aa. Equivalent to Rv2538c,
                     len: 362 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 362 aa overlap). aroB,
                     3-dehydroquinate synthase (EC 4.2.3.4) (see citation
                     below), equivalent to Q9CCS4|AROB_MYCLE|ML0518
                     3-DEHYDROQUINATE SYNTHASE from Mycobacterium leprae (361
                     aa), FASTA scores: opt: 2059, E(): 3.3e-117, (87.25%
                     identity in 361 aa overlap). Also highly similar to many
                     e.g. Q9KXQ6|AROB from Streptomyces coelicolor (363 aa),
                     FASTA scores: opt: 1363, E(): 4e-75, (60.05% identity in
                     358 aa overlap); Q9X5D2|AROB_CORGL from Corynebacterium
                     glutamicum (Brevibacterium flavum) (366 aa), FASTA scores:
                     opt: 1154, E(): 1.7e-62, (50.95% identity in 359 aa
                     overlap); P07639|AROB_ECOLI|B3389 from Escherichia coli
                     strain K12 (362 aa), FASTA scores: opt: 771, E(): 2.4e-39,
                     (40.6% identity in 345 aa overlap); etc. BELONGS TO THE
                     DEHYDROQUINATE SYNTHASE FAMILY. Protein product from
                     Mb2567c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb2567c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A4Z5"
                     /db_xref="InterPro:IPR016037"
                     /db_xref="InterPro:IPR030960"
                     /db_xref="InterPro:IPR030963"
                     /db_xref="UniProtKB/Swiss-Prot:P0A4Z5"
BEGIN
        1 MTDIGAPVTV QVAVDPPYPV VIGTGLLDEL EDLLADRHKV AVVHQPGLAE TAEEIRKRLA
       61 GKGVDAHRIE IPDAEAGKDL PVVGFIWEVL GRIGIGRKDA LVSLGGGAAT DVAGFAAATW
      121 LRGVSIVHLP TTLLGMVDAA VGGKTGINTD AGKNLVGAFH QPLAVLVDLA TLQTLPRDEM
      181 ICGMAEVVKA GFIADPVILD LIEADPQAAL DPAGDVLPEL IRRAITVKAE VVAADEKESE
      241 LREILNYGHT LGHAIERRER YRWRHGAAVS VGLVFAAELA RLAGRLDDAT AQRHRTILSS
      301 LGLPVSYDPD ALPQLLEIMA GDKKTRAGVL RFVVLDGLAK PGRMVGPDPG LLVTAYAGVC
      361 AP
//