LOCUS SIU01181.1 372 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable
cytoplasmic peptidase pepq protein.
ACCESSION LT708304-2595
PROTEIN_ID SIU01181.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="pepQ"
/locus_tag="BQ2027_MB2564C"
/note="Mb2564c, pepQ, len: 372 aa. Equivalent to Rv2535c,
len: 372 aa, from Mycobacterium tuberculosis strain H37Rv,
(100.0% identity in 372 aa overlap). Probable pepQ,
cytoplasmic peptidase (EC 3.4.-.-), equivalent to
Q9CCS1|PEPQ|ML0521 PUTATIVE CYTOPLASMIC PEPTIDASE from
Mycobacterium leprae (376 aa), FASTA scores: opt: 1954,
E(): 1.1e-105, (82.7% identity in 376 aa overlap). Also
similar to other peptidases e.g. P54518|YQHT_BACSU
PUTATIVE PEPTIDASE (BELONGS TO PEPTIDASE FAMILY M24B) from
Bacillus subtilis (353 aa), FASTA scores: opt: 808, E():
1.6e-39, (39.65% identity in 368 aa overlap);
Q9KXQ8|SC9C5.16c PUTATIVE PEPTIDASE from Streptomyces
coelicolor (368 aa), FASTA scores: opt: 803, E(): 3.2e-39,
(43.15% identity in 380 aa overlap); Q9K950|BH2800 XAA-PRO
DIPEPTIDASE from Bacillus halodurans (355 aa), FASTA
scores: opt: 801, E(): 4.1e-39, (39.45% identity in 365 aa
overlap); etc. Note that second part of protein is similar
to second part of MTCY49.29c|Rv2089c|MT2150|MTCY49.29c
PROBABLE DIPEPTIDASE (EC 3.4.13.-; BELONGS TO PEPTIDASE
FAMILY M24B) from Mycobacterium tuberculosis (375 aa)
(33.9% identity in 354 aa overlap) BLAST RESULTS: Score:
142 bits (359), E: 4e-33, Identities: 86/224 (38%),
Positives: 119/224 (52%), Gaps: 4/224 (1%). COULD BE
BELONG TO PEPTIDASE FAMILY M24B. Protein product from
Mb2564c detected using shotgun mass spectrometry and SWATH
mass spectrometry. Mb2564c found to be expressed during
exponential growth in Sauton's minimal media by
RNA-sequencing."
/db_xref="GOA:A0A1R3Y1H0"
/db_xref="InterPro:IPR000587"
/db_xref="InterPro:IPR000994"
/db_xref="InterPro:IPR001131"
/db_xref="InterPro:IPR001714"
/db_xref="InterPro:IPR029149"
/db_xref="InterPro:IPR036005"
/db_xref="UniProtKB/TrEMBL:A0A1R3Y1H0"
BEGIN
1 MTHSQRRDKL KAQIAASGLD AMLISDLINV RYLSGFSGSN GALLVFADER DAVLATDGRY
61 RTQAASQAPD LEVAIERAVG RYLAGRAGEA GVGKLGFESH VVTVDGLDAL AGALEGKNTE
121 LVRASGTVES LREVKDAGEL ALLRLACEAA DAALTDLVAR GGLRPGRTER QVSRELEALM
181 LDHGADAVSF ETIVAAGANS AIPHHRPTDA VLQVGDFVKI DFGALVAGYH SDMTRTFVLG
241 KAADWQLEIY QLVAEAQQAG RQALLPGAEL RGVDAAARQL IADAGYGEHF GHGLGHGVGL
301 QIHEAPGIGV TSAGTLLAGS VVTVEPGVYL PGRGGVRIED TLVVAGGTPK MPETAGQTPE
361 LLTRFPKELA IL
//