LOCUS SIU01175.1 139 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 possible toxin vapc39. contains pin domain. protein. ACCESSION LT708304-2589 PROTEIN_ID SIU01175.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="vapc39" /locus_tag="BQ2027_MB2559C" /note="Mb2559c, -, len: 139 aa. Equivalent to Rv2530c, len: 139 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 139 aa overlap). Conserved hypothetical protein, highly similar to two HYPOTHETICAL PROTEINS from Mycobacterium tuberculosis (strains H37Rv and CDC1551): O53219|Rv2494|MTV008.50 (141 aa), FASTA scores: opt: 380, E(): 3.6e-19, (48.0% identity in 125 aa overlap); and O53372|Rv3320c|MTV016.20c (142 aa), FASTA scores: opt: 286, E(): 9.3e-13, (41.35% identity in 133 aa overlap); and similar to others e.g. O07760|Rv0617|MTCY19H5.04c (133 aa), FASTA scores: opt: 158, E(): 0.00048, (39.55% identity in 129 aa overlap). Also some similarity with CAC48798|SMB20412 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (54 aa), FASTA scores: opt: 184, E(): 3.7e-06, (53.85% identity in 52 aa overlap); and CAC48797|SMB20411 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (82 aa), FASTA scores: opt: 170, E(): 4.8e-05, (44.45% identity in 63 aa overlap). Protein product from Mb2559c detected using SWATH mass spectrometry. Mb2559c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y3K9" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR006226" /db_xref="InterPro:IPR022907" /db_xref="InterPro:IPR029060" /db_xref="UniProtKB/TrEMBL:A0A1R3Y3K9" BEGIN 1 MTALLDVNVL IALGWPNHVH HAAAQRWFTQ FSSNGWATTP ITEAGYVRIS SNRSVMQVST 61 TPAIAIAQLA AMTSLAGHTF WPDDVPLIVG SAGDRDAVSN HRRVTDCHLI ALAARYGGRL 121 VTFDAALADS ASAGLVEVL //