LOCUS       SIU01175.1               139 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 possible
            toxin vapc39. contains pin domain. protein.
ACCESSION   LT708304-2589
PROTEIN_ID  SIU01175.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="vapc39"
                     /locus_tag="BQ2027_MB2559C"
                     /note="Mb2559c, -, len: 139 aa. Equivalent to Rv2530c,
                     len: 139 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 139 aa overlap). Conserved
                     hypothetical protein, highly similar to two HYPOTHETICAL
                     PROTEINS from Mycobacterium tuberculosis (strains H37Rv
                     and CDC1551): O53219|Rv2494|MTV008.50 (141 aa), FASTA
                     scores: opt: 380, E(): 3.6e-19, (48.0% identity in 125 aa
                     overlap); and O53372|Rv3320c|MTV016.20c (142 aa), FASTA
                     scores: opt: 286, E(): 9.3e-13, (41.35% identity in 133 aa
                     overlap); and similar to others e.g.
                     O07760|Rv0617|MTCY19H5.04c (133 aa), FASTA scores: opt:
                     158, E(): 0.00048, (39.55% identity in 129 aa overlap).
                     Also some similarity with CAC48798|SMB20412 CONSERVED
                     HYPOTHETICAL PROTEIN from Rhizobium meliloti
                     (Sinorhizobium meliloti) plasmid pSymB (54 aa), FASTA
                     scores: opt: 184, E(): 3.7e-06, (53.85% identity in 52 aa
                     overlap); and CAC48797|SMB20411 CONSERVED HYPOTHETICAL
                     PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti)
                     plasmid pSymB (82 aa), FASTA scores: opt: 170, E():
                     4.8e-05, (44.45% identity in 63 aa overlap). Protein
                     product from Mb2559c detected using SWATH mass
                     spectrometry. Mb2559c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3K9"
                     /db_xref="InterPro:IPR002716"
                     /db_xref="InterPro:IPR006226"
                     /db_xref="InterPro:IPR022907"
                     /db_xref="InterPro:IPR029060"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3K9"
BEGIN
        1 MTALLDVNVL IALGWPNHVH HAAAQRWFTQ FSSNGWATTP ITEAGYVRIS SNRSVMQVST
       61 TPAIAIAQLA AMTSLAGHTF WPDDVPLIVG SAGDRDAVSN HRRVTDCHLI ALAARYGGRL
      121 VTFDAALADS ASAGLVEVL
//