LOCUS SIU01155.1 215 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 oligoribonuclease orn protein. ACCESSION LT708304-2569 PROTEIN_ID SIU01155.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="orn" /locus_tag="BQ2027_MB2539" /note="Mb2539, orn, len: 215 aa. Equivalent to Rv2511, len: 215 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 215 aa overlap). Probable orn, oligoribonuclease (EC 3.1.-.-), equivalent to O07708|ORN_MYCLE|ORN|ML0427|MLCL383.34c OLIGORIBONUCLEASE from Mycobacterium leprae (215 aa), FASTA scores: opt: 1170, E(): 3.5e-65, (84.5% identity in 213 aa overlap). Also highly similar to many e.g. P57667|ORN_STRGR|ORNA from Streptomyces griseus (201 aa), FASTA scores: opt: 807, E(): 7.7e-43, (59.0% identity in 200 aa overlap); ORN_STRCO|ORNA|2SC13.01 from Streptomyces coelicolor (200 aa), FASTA scores: opt: 799, E(): 2.4e-42, (59.7% identity in 201 aa overlap); P39287|ORN_ECOLI|B4162 from Escherichia coli strain K12 (180 aa), FASTA scores: opt: 519, E(): 3.9e-25, (47.4% identity in 173 aa overlap); etc. BELONGS TO THE OLIGORIBONUCLEASE FAMILY. Protein product from Mb2539 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2539 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P65598" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR022894" /db_xref="InterPro:IPR036397" /db_xref="UniProtKB/Swiss-Prot:P65598" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MQDELVWIDC EMTGLDLGSD KLIEIAALVT DADLNILGDG VDVVMHADDA ALSGMIDVVA 61 EMHSRSGLID EVKASTVDLA TAEAMVLDYI NEHVKQPKTA PLAGNSIATD RAFIARDMPT 121 LDSFLHYRMI DVSSIKELCR RWYPRIYFGQ PPKGLTHRAL ADIHESIREL RFYRRTAFVP 181 QPGPSTSEIA AVVAELSDGA GAQEETDSAE APQSG //