LOCUS SIU01152.1 445 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE CONSERVED INTEGRAL MEMBRANE LEUCINE AND ALANINE RICH PROTEIN protein. ACCESSION LT708304-2566 PROTEIN_ID SIU01152.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2536C" /note="Mb2536c, -, len: 445 aa. Equivalent to Rv2508c, len: 445 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 445 aa overlap). Probable conserved integral membrane leu-, ala-rich protein, equivalent to Q9CCU4|ML0430 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (454 aa) (alias O07710|MLCL383.37 longer 10 aa), FASTA scores: opt: 2205, E(): 2.5e-124, (75.75% identity in 441 aa overlap). Also similar to hypothetical or membrane proteins e.g. BAB50841|MLL4103 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (458 aa), FASTA scores: opt: 396, E(): 2.4e-16, (27.75% identity in 447 aa overlap); Q9RKX9|SC6D7.19c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (486 aa), FASTA scores: opt: 323, E(): 5.7e-12, (28.95% identity in 428 aa overlap); P42306|YXIO_BACSU PROBABLE INTEGRAL MEMBRANE PROTEIN from Bacillus subtilis (428 aa), FASTA scores: opt: 220, E(): 7.2e-06, (20.35% identity in 413 aa overlap); etc. Also similar to proteins from Mycobacterium tuberculosis e.g. Q10564|Y876_MYCTU|Rv0876c|MT0899|MTCY31. 04c (548 aa), FASTA scores: opt: 184, E(): 0.0012, (24.7% identity in 466 aa overlap). Mb2536c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y1F8" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="UniProtKB/TrEMBL:A0A1R3Y1F8" BEGIN 1 MNNPGSRAGT LLHFRVVAWA MWDCGSTGLN AIVTTFVFSV YLTSAVGQGL PGGTSPASWL 61 GRAGAVAGLT IGVLAPVVGV WVESPHRRRV ALSVLTGTAV ALTCAMFLIR DDPRYLWAGL 121 VLLAATAASS DLSSVPYNAM LRQLSTPSTA GRISGFGWAS GYVGSVALLL VIYLGFMSGS 181 GSQRGLLQLP VANGLNVRMA MLVAAAWLAL LGLPLLLVAH RLPDSGAASH PSTGLLGGYR 241 KLWTEISAEW RRDRNLVYFL VASAIFRDGL AAIFAFGAVL GVNAYGLTQA DVLIFGAAAS 301 VVAAVGAVLG GFVDHRIGSK PVIVGSLAAI IAAALTLLTL SGPTAFWACG LLLCVFIGPA 361 QSSARALLLH MAQHGKEGVA FGLYTMTGRA VSFLGPWLFS VFVDVFHTVR AGLGGVCLVL 421 TTGLLLMLRV QVSRHGGALT TAQSS //