LOCUS       SIU01152.1               445 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED INTEGRAL MEMBRANE LEUCINE AND ALANINE RICH PROTEIN
            protein.
ACCESSION   LT708304-2566
PROTEIN_ID  SIU01152.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2536C"
                     /note="Mb2536c, -, len: 445 aa. Equivalent to Rv2508c,
                     len: 445 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 445 aa overlap). Probable conserved
                     integral membrane leu-, ala-rich protein, equivalent to
                     Q9CCU4|ML0430 PUTATIVE MEMBRANE PROTEIN from Mycobacterium
                     leprae (454 aa) (alias O07710|MLCL383.37 longer 10 aa),
                     FASTA scores: opt: 2205, E(): 2.5e-124, (75.75% identity
                     in 441 aa overlap). Also similar to hypothetical or
                     membrane proteins e.g. BAB50841|MLL4103 HYPOTHETICAL
                     PROTEIN from Rhizobium loti (Mesorhizobium loti) (458 aa),
                     FASTA scores: opt: 396, E(): 2.4e-16, (27.75% identity in
                     447 aa overlap); Q9RKX9|SC6D7.19c PUTATIVE INTEGRAL
                     MEMBRANE PROTEIN from Streptomyces coelicolor (486 aa),
                     FASTA scores: opt: 323, E(): 5.7e-12, (28.95% identity in
                     428 aa overlap); P42306|YXIO_BACSU PROBABLE INTEGRAL
                     MEMBRANE PROTEIN from Bacillus subtilis (428 aa), FASTA
                     scores: opt: 220, E(): 7.2e-06, (20.35% identity in 413 aa
                     overlap); etc. Also similar to proteins from Mycobacterium
                     tuberculosis e.g. Q10564|Y876_MYCTU|Rv0876c|MT0899|MTCY31.
                     04c (548 aa), FASTA scores: opt: 184, E(): 0.0012, (24.7%
                     identity in 466 aa overlap). Mb2536c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y1F8"
                     /db_xref="InterPro:IPR024671"
                     /db_xref="InterPro:IPR036259"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1F8"
BEGIN
        1 MNNPGSRAGT LLHFRVVAWA MWDCGSTGLN AIVTTFVFSV YLTSAVGQGL PGGTSPASWL
       61 GRAGAVAGLT IGVLAPVVGV WVESPHRRRV ALSVLTGTAV ALTCAMFLIR DDPRYLWAGL
      121 VLLAATAASS DLSSVPYNAM LRQLSTPSTA GRISGFGWAS GYVGSVALLL VIYLGFMSGS
      181 GSQRGLLQLP VANGLNVRMA MLVAAAWLAL LGLPLLLVAH RLPDSGAASH PSTGLLGGYR
      241 KLWTEISAEW RRDRNLVYFL VASAIFRDGL AAIFAFGAVL GVNAYGLTQA DVLIFGAAAS
      301 VVAAVGAVLG GFVDHRIGSK PVIVGSLAAI IAAALTLLTL SGPTAFWACG LLLCVFIGPA
      361 QSSARALLLH MAQHGKEGVA FGLYTMTGRA VSFLGPWLFS VFVDVFHTVR AGLGGVCLVL
      421 TTGLLLMLRV QVSRHGGALT TAQSS
//